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There’s a new theory about why some cancer therapies fail. It’s about timing.

One of the most disheartening things about cancer care today is the amount of guesswork that goes into drug treatments. It isn't uncommon for patients to go through two, three or more therapies before finding success or running out of time. Scientists now know that genetics explain why some drugs may work work miraculously in one person […]
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Tags: newsletter cancer Source Type: news

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Publication date: Available online 22 May 2018 Source:Acta Pharmaceutica Sinica B Author(s): Xiao-Mei Qi, Fang Wang, Matthew Mortensen, Ryan Wertz, Guan Chen Protein kinases and phosphatases signal by phosphorylation and dephosphorylation to precisely control the activities of their individual and common substrates for a coordinated cellular outcome. In many situations, a kinase/phosphatase complex signals dynamically in time and space through their reciprocal regulations and their cooperative actions on a substrate. This complex may be essential for malignant transformation and progression and can therefore be considered...
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Yalei Miao, Yudian Qiu, Wenjing Yang, Yuqi Guo, Hongwei Hou, Zhongyi Liu, Xubo Zhao Dual pH-/reduction-sensitive biodegradable poly(methacrylic acid-co-N,N-bis(acryloyl)cystamine)/chitosan/dimethylmaleic anhydride-modified chitosan (PMAABACy/CS/CS-DMMA) nanoparticles with PMAABACy cores as carriers and dimethylmaleic anhydride-modified chitosan as charge reversible shells were rationally designed. PMAABACy cores using N,N-Bis(acryloyl)cystamine (BACy) as a crosslinker and methacrylic acid (MAA) as a monomer were fabrica...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
  Purdue University is reporting on a new method of targeting cancer cells, developed by scientists in its Nuclear Engineering department. Dubbed PLASMAT, the technique combines cold atmospheric plasma, an ionized gas that brings with it active ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Surgery Source Type: blogs
Authors: Li Q, Wu J, Chen S, Zhao Y Abstract The introduction of the theory of cancer stem cells (CSCs) has provided a new direction and perspective for our understanding of the nature and origin of tumors. Cancer stem cells are believed to be responsible for the treatment failure, drug tolerance, metastasis, and recurrence of tumors. However, it remains a challenge to identify or isolate tumor stem cells and determine their regulatory mechanisms. Therefore, further understanding of the biological characteristics and functions of CSCs is of great practical significance and value to develop new methods of tumor diag...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Preclinical tumor models are the foundation of translational cancer research. For exploring fundamental biologic mechanisms or designing new cancer therapies, in  vitro and in vivo models are the indispensable test environments in which countless discoveries have been made. Conventional models rely on immortalized cell lines that are notable for their reproducibility, convenience, and ease of use. Although these approaches continue to be widely used, their limitations are well known. In particular, these models are often criticized as poor reproductions of clinical tumors.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Research in Translation Source Type: research
AbstractHyperthermia is a promising alternative modality for the conventional cancer treatments. Nanoparticle-mediated photothermal therapy (PTT) has been widely applied for hyperthermia cancer therapy by a near-infrared light irradiation. Some special nanoparticles can convert light energy into heat and destroy the tumor cells. Inspired from the photothermal efficacy of the gold nanoparticles, here we synthesized, characterized, and applied novel photothermal polyethylene glycol-curcumin-gold nanoparticles (PEG-Cur-Au NPs) in cancer PTT. The effect of PEG-Cur-Au NPs upon irradiation by an 808-nm laser on C540 (B16/F10) ce...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
Senolytic compounds are those capable of selectively destroying senescent cells. They are useful because the buildup of senescent cells over time is one of the root causes of aging. A number of mechanisms have been discovered by which senescent cells can be provoked into self-destruction, such as bcl-2 inhibition or interference in FOXO4-p53 interactions. These examples are fairly well understood. Other mechanisms are known but less well understood; they require more work in order to proceed on the production of improved senolytic compounds. In some cases, however, the primary mechanism of action of a compound found...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Publication date: Available online 20 May 2018 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Cristina Amaral, Tiago Vieira Augusto, Elisiário Tavares-da-Silva, Fernanda M.F. Roleira, Georgina Correia-da-Silva, Natércia Teixeira The leading cause of cancer death in women around the world is breast cancer. The aromatase inhibitors (AIs) are considered a first-line treatment for estrogen receptor-positive (ER+) breast tumors, in postmenopausal women. Exemestane (Exe) is a powerful steroidal AI, however, despite its therapeutic success, Exe-acquired resistance may occur leading to t...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: 1 August 2018 Source:Life Sciences, Volume 206 Author(s): Qian Zhou, Chaoqun You, Cong Zheng, Yawen Gu, Hongchao Gu, Rui Zhang, Hongshuai Wu, Baiwang Sun DNA is considered to be one of the most promising targets for anticancer agents. Acridine analogues have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clinical usage and the mechanisms of action are not fully understood. Novel acridine derivatives are needed for effective cancer therapy. A series of novel 3-nitroacridine-based derivati...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Yiwen Li, Huailin Yang, Jiuxu Yao, Haiyang Yu, Xin Chen, Peng Zhang, Chunsheng Xiao An amphiphilic biodegradable prodrug (PLG-g-mPEG/CPT) was synthesized by conjugating disulfide-containing camptothecin (CPT) to poly(L-glutamic acid)-graft-methoxy poly(ethylene glycol) (PLG-g-mPEG) through esterification reaction. The amphiphilic prodrugs could self-assemble into micellar nanoparticles and encapsulate doxorubicin (DOX) in aqueous solution at pH 7.4. The treatment of the nanoparticles with reducing glutathione (GSH) at c...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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