Role and Regulation of the NLRP3 Inflammasome.

Immunology Interest Group Gabriel Nuñez earned his M.D. degree from the University of Seville, Spain, in 1977. He received postdoctoral training in Immunology at the University of Texas Southwestern Medical Center, Dallas (1979–1984) and residency training in Anatomical Pathology at Washington University in St Louis (1985–1990). In 1987, he joined the laboratory of Stanley Korsmeyer at Washington University, where he studied the function of the anti-apoptotic protein BCL-2. In 1991, he joined the Department of Pathology at the University of Michigan in Ann Arbor as an Assistant Professor and was promoted to full Professor in 2001. He holds the Paul de Kruif Endowed Professorship in Academic Pathology. The Nuñez laboratory is interested in signaling pathways regulating innate immunity, the pathogenesis of inflammatory disease and cancer. Specifically, the research focuses on mechanistic studies to understand the role of pattern recognition receptors (PRRs) including Nod-like receptors (NLRs) and Toll-like receptors (TLRs) in the host immune response against microbial pathogens and endogenous damage signals. His laboratory identified NOD1 and NOD2, the first members of the Nod-like receptor (NLR) family, a class of pattern-recognition receptors that mediate cytosolic sensing of microbial organisms and showed that genetic variation in a NLR family member, NOD2, is strongly associated with susceptibility to Crohn's disease. Current studies focus on models of intestinal, sk...
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