Acute Oral Toxicity Testing of Ethyl Acetate Fraction from Garcinia mangostana Linn Extract in Sprague-Dawley Rats

Garcinia mangostana-Linn (GM) or commonly known as Manggis by Indonesian, is a tropical tree native to Southeast Asia. It produces a fruit, whose pericarp contains tricyclic isoprenylated polyphenol or xanthones. The toxicity’s evaluation of the ethyl acetate fraction from GM pericarp extract was needed before therapeutic use. The purpose of this article is to examine the oral acute toxicity test. The acute toxicity test was conducted in female sprague-dawley rats as per standard protocol. One group of rats administered single dose of 8 mg kg–1 b.wt. and the second group with a single dose of 18 mg kg–1 b.wt., of ethyl acetate fraction of GM extract, administrated orally and one control group. Body weight, behavioral changes and mortality were observed for 14 days. Dietary and water intake were also noted. At the end of the study, rats were sacrificed by decapitation. The result of this study showed that the Lethal Dose (LD50) was found to be>15.480 mg kg–1 b.wt. There was a significant weight increase (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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CONCLUSIONS: Perceived devaluation was extremely prevalent among street-involved youth in our sample. We also observed that youth most in need of health and social services were significantly more likely to report high levels of perceived devaluation which may result in a reluctance to seek out key services and supports. These findings highlight the need to implement stigma reduction interventions for vulnerable youth in this setting. PMID: 30526206 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Conclusion/importance: This work is significant in expanding the populations thought to be impacted by and understanding social disparities related to SC use. Further investigation is needed to assess the relationship between concomitant use of SC and other drug, particularly opiates. This may suggest that the sequelae of one drug may enhance or alleviate the effects of the other. PMID: 30526203 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Source: Current Psychiatry Reviews - Category: Psychiatry Authors: Tags: Articles Source Type: research
Source: Current Psychiatry Reviews - Category: Psychiatry Authors: Tags: Editorial Source Type: research
Source: Current Psychiatry Reviews - Category: Psychiatry Authors: Tags: Review article Source Type: research
Source: Current Psychiatry Reviews - Category: Psychiatry Authors: Tags: Review article Source Type: research
Source: Current Psychiatry Reviews - Category: Psychiatry Authors: Tags: Review article Source Type: research
Source: Current Psychiatry Reviews - Category: Psychiatry Authors: Tags: Review article Source Type: research
Source: Current Psychiatry Reviews - Category: Psychiatry Authors: Tags: Review article Source Type: research
Source: Current Psychiatry Reviews - Category: Psychiatry Authors: Tags: Review article Source Type: research
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