Acute Oral Toxicity Testing of Ethyl Acetate Fraction from Garcinia mangostana Linn Extract in Sprague-Dawley Rats
Garcinia mangostana-Linn (GM) or commonly known as Manggis by Indonesian, is a tropical tree native to Southeast Asia. It produces a fruit, whose pericarp contains tricyclic isoprenylated polyphenol or xanthones. The toxicitys evaluation of the ethyl acetate fraction from GM pericarp extract was needed before therapeutic use. The purpose of this article is to examine the oral acute toxicity test. The acute toxicity test was conducted in female sprague-dawley rats as per standard protocol. One group of rats administered single dose of 8 mg kg1 b.wt. and the second group with a single dose of 18 mg kg1 b.wt., of ethyl acetate fraction of GM extract, administrated orally and one control group. Body weight, behavioral changes and mortality were observed for 14 days. Dietary and water intake were also noted. At the end of the study, rats were sacrificed by decapitation. The result of this study showed that the Lethal Dose (LD50) was found to be>15.480 mg kg1 b.wt. There was a significant weight increase (p
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Mazars USA LLP is expected to start work Monday at District-owned United Medical Center after D.C. Council members approved the company's operating contract late Friday. It followed a D.C. Council health committee hearing earlier that day, when officials from the New York-based auditing firm worked to prove they were the right pick for a $5 million, eight-month contract to oversee operations at the hospital and replace previous, controversial operator, Veritas of Washington LLC. "We know that…
CONCLUSION: The newly developed questionnaire can facilitate the diagnosis in patients with suspicion on interstitial lung disease in clinical routine. PMID: 29466814 [PubMed - as supplied by publisher]
Authors: Kropp R PMID: 29466813 [PubMed - as supplied by publisher]
This report is describing the case of a patient who developed parallel two different mechanisms of resistance: A T790 M resistance mutation and a transformation into a small cell neuroendocrine cancer. Under therapy with Osimertinib and chemotherapy with carboplatin and etoposide the tumor responsed partially. PMID: 29466812 [PubMed - as supplied by publisher]
21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Geriatr Psychiatry These pubmed results were generated on 2018/02/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Soft Matter, 2018, Accepted Manuscript DOI: 10.1039/C7SM02317K, PaperAvinash Yashwant Gahane, Pritish Ranjan, Virender Singh, Raj Kumar Sharma, Neeraj Sinha, Mandeep Sharma, Rama Chaudhry, Ashwani Kumar Thakur A In the quest for new antimicrobial materials, hydrogels of Fmoc-protected peptides and amino acids have gained momentum due to their ease of synthesis and being cost effective. But their... The content of this RSS Feed (c) The Royal Society of Chemistry
J. Mater. Chem. A, 2018, Accepted Manuscript DOI: 10.1039/C7TA11095B, PaperIl Jeon, Ryohei Sakai, Seungju Seo, Graham Edward Morse, Hiroshi Ueno, Takafumi Nakagawa, Yang Qian, Shigeo Maruyama, Yutaka Matsuo High-performance air-stable PBTZT-stat-BDTT-8 organic solar cells were fabricated using mixed C60/C70 fullerene acceptors. Normal-architecture devices using PBTZT-stat-BDTT-8 with PC71BM produced a power conversion efficiency (PCE) of 9.38%. Inverted-architecture, which possess... The content of this RSS Feed (c) The Royal Society of Chemistry
CrystEngComm, 2018, Accepted Manuscript DOI: 10.1039/C7CE02189E, CommunicationRen-Bin Zhou, Xiao-Li Lu, Chen Dong, Ahmad Fiaz, Chen-Yan Zhang, Da-Chuan Yin Protein crystallization screens are commonly used to find specific crystallization conditions. In practice, the undesirable clear drops are often ignored. We hypothesize that clear drops may be potentially useful for... The content of this RSS Feed (c) The Royal Society of Chemistry
A new mother says she pulled blood-soaked bandages from her body, seven weeks after giving birth.