Abstract A44: Clinical significance of ESR1 mutations by cell-free DNA in recurrent/metastatic breast cancer

Conclusions: We demonstrated the sensitive detection and accurate quantification of low frequency ESR1 mutations in 33 tumor tissues and the corresponding cell-free DNA (cfDNA) using ddPCR assay in recurrent/ metastatic breast cancer. Our results highlight that ESR1 mutations may be of clinical relevance for metastatic breast cancer patient.Citation Format: Takashi Takeshita, Yutaka Yamamoto, Mutsuko Yamamoto-Ibusuki, Toko Inao, Aiko Sueta, Saori Fujiwara, Hirotaka Iwase. Clinical significance of ESR1 mutations by cell-free DNA in recurrent/metastatic breast cancer. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Breast Cancer Research; Oct 17-20, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(2_Suppl):Abstract nr A44.

Source: Molecular Cancer Research - February 29, 2016 Category: Cancer & Oncology Authors: Takeshita, T., Yamamoto, Y., Yamamoto-Ibusuki, M., Inao, T., Sueta, A., Fujiwara, S., Iwase, H. Tags: Monitoring Metastasis and CTCs: Poster Presentations - Proffered Abstracts Source Type: research