Abstract A09: Development of novel breast cancer brain-metastases-derived xenografts and cell lines

Conclusions: We have developed novel PDXs derived from breast cancer brain metastases, which retain their ability to colonize the brain when disseminated in circulation. These novel GFP-luciferase labeled xenografts and cell lines, represent unique tools to study brain metastasis biology and to test novel therapeutic treatments for brain metastasis in clinically relevant models.Citation Format: Colton Hanna, Britta M. Jacobsen, Carol A. Sartorius, Peter Kabos, Kevin Lillehei, David R. Ormond, Michael Graner, Virginia F. Borges, Diana M. Cittelly. Development of novel breast cancer brain-metastases-derived xenografts and cell lines. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Breast Cancer Research; Oct 17-20, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(2_Suppl):Abstract nr A09.

Source: Molecular Cancer Research - February 29, 2016 Category: Cancer & Oncology Authors: Hanna, C., Jacobsen, B. M., Sartorius, C. A., Kabos, P., Lillehei, K., Ormond, D. R., Graner, M., Borges, V. F., Cittelly, D. M. Tags: Animal Models: Poster Presentations - Proffered Abstracts Source Type: research