Significance of chemokine and chemokine receptors in head and neck squamous cell carcinoma: A critical review

Squamous cell carcinoma (SCC) is the most common malignancy of head and neck region arising from mucosal linings of the upper aerodigestive tract, comprising (1) nasal cavity and paranasal sinuses, (2) nasopharynx, (3) hypopharynx, larynx, and trachea, and (4) oral cavity and oropharynx [1,2]. Head and neck squamous cell carcinomas (HNSCC) are characterized by high morbidity and mortality rates and strong tendency to regional and distant metastasis [1–4]. These tumor characteristics depend on individual properties of neoplastic cells and tumor microenvironment, which is comprised by diverse inflammatory/immune cells population; stromal cells; cancer stem cells; nutrients, growth factors, and a network of cytokines and chemokines [5–7].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research