Resistance and virulence potential of uropathogenic Escherichia coli strains isolated from patients hospitalized in urology departments: a French prospective multicenter study.

Resistance and virulence potential of uropathogenic Escherichia coli strains isolated from patients hospitalized in urology departments: a French prospective multicenter study. J Med Microbiol. 2016 Mar 7; Authors: Lavigne JP, Bruyère F, Bernard L, Combescure C, Ronco E, Lanotte P, Coloby P, Thibault M, Cariou G, Desplaces N, Costa P, Sotto A Abstract We characterized antibiotic resistance and virulence of uropathogenic E. coli (UPEC) strains isolated from urinary tract infection (UTI) in patients hospitalized in urology Departments. A prospective multicenter study was initiated from March 2009 and lasted through February 2010 in French urology units. All patients with asymptomatic bacteriuria (ABU), acute cystitis, acute pyelonephritis or acute prostatitis in whom UPEC was detected, were included. Antimicrobial resistance and virulence factors were compared between the different groups. To identify independent associations between virulence markers and risk of UTI, we used a multivariate logistic regression. We included 210 patients (mean age: 65.8 years; 106 female). ABU was diagnosed in 67 cases (31.9%), cystitis in 52 cases (24.7%), pyelonephritis in 35 cases (16.7%) and prostatitis in 56 cases (26.7%). ABU was more frequent in patients with urinary catheter (76.1% vs 23.9%, p<0.001). The resistance rate was 7.6% and 24,8% for cefotaxime (CTX) and for ciprofloxacin (CIP), respectively. UPEC isolated from infections belonged m...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research