Facial and Efficient Access to Dihydropyrano[3,2-c]chromenes via Three-Component Reaction Using N,N-Dimethylbenzylamine As a New Organocatalyst.

Facial and Efficient Access to Dihydropyrano[3,2-c]chromenes via Three-Component Reaction Using N,N-Dimethylbenzylamine As a New Organocatalyst.
Comb Chem High Throughput Screen. 2016 Mar 10;
Authors: Kiyani H, Jalali M
Abstract
The N,N-dimethylbenzylamine (DMBA), as an efficient and commercially available organocatalyst was employed for the one-pot synthesis of dihydropyrano[3,2-c]chromene derivatives in ethanol medium. In this work, the one-pot Knoevenagel-Michael-Thorpe-Ziegler type cascade heterocyclization has been developed for the synthesis of dihydropyrano[3,2-c]chromene-containing heterocycles from the one-pot multicomponent condensation reaction of 4-hydroxycoumarin, malononitrile/ethyl cyanoacetate, and various aldehydes at 60 °C. The salient features of this base-catalyzed reaction are mild reaction conditions, reusability of the reaction medium, shorter reaction times, and easy separation of the reaction mixture.
PMID: 26961823 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - March 10, 2016 Category: Chemistry Authors: Kiyani H, Jalali M Tags: Comb Chem High Throughput Screen Source Type: research