Countermeasures Against Chemical Threats (CounterACT): Optimization of Therapeutic Lead Compounds (U01)

Funding Opportunity Number: PAR-16-128 Opportunity Category: DiscretionaryFunding Instrument Type: Cooperative AgreementCategory of Funding Activity: EnvironmentHealthCFDA Number: 93.11393.84693.85393.867Eligible Applicants State governmentsCounty governmentsCity or township governmentsSpecial district governmentsIndependent school districtsPublic and State controlled institutions of higher educationNative American tribal governments (Federally recognized)Public housing authorities/Indian housing authoritiesNative American tribal organizations (other than Federally recognized tribal governments)Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationPrivate institutions of higher educationFor profit organizations other than small businessesSmall businessesOthers (see text field entitled "Additional Information on Eligibility" for clarification)Agency Name: HHS-NIH11Closing Date: Sep 11, 2018Award Ceiling: Expected Number of Awards: Creation Date: Mar 10, 2016Funding Opportunity Description: The mission of the NIH Countermeasures Against Chemical Threats (CounterACT) program is to develop new and improved therapeutics to treat and/or prevent injuries resulting from exposure to chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial ...
Source: Grants.gov - Category: Research Tags: Environment Health Source Type: funding

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Corrigendum to "About the French prohibition of textured breast implants: Is it justified or over-cautious? The EUSOMA, ESSO/BRESSO position" [Breast 46 (August 2019) 95-96]. Breast. 2019 Dec;48:103 Authors: Cardoso MJ, Biganzoli L, Rubio IT, Leidenius M, Curigliano G, Cutuli B, Marotti L, Kovacs T, Wyld L PMID: 31706464 [PubMed - in process]
Source: Breast - Category: Cancer & Oncology Authors: Tags: Breast Source Type: research
Corrigendum to "EUSOMA position regarding breast implant associated anaplastic large cell lymphoma (BIA-ALCL) and the use of textured implants" [Breast 44 (April 2019) 90-93]. Breast. 2019 Dec;48:102 Authors: Cardoso MJ, Wyld L, Rubio IT, Leidenius M, Curigliano G, Cutuli B, Marotti L, Biganzoli L PMID: 31706463 [PubMed - in process]
Source: Breast - Category: Cancer & Oncology Authors: Tags: Breast Source Type: research
Publication date: Available online 11 November 2019Source: Journal of Orthopaedic TranslationAuthor(s): Hongyun Huang, Wise Young, Stephen Skaper, Lin Chen, Gustavo Moviglia, Hooshang Saberi, Ziad Al-Zoubi, Hari Shanker Sharma, Dafin Muresanu, Alok Sharma, Wagih El Masry, Shiqing Feng, International Association of Neurorestoratology and The Chinese Association of NeurorestoratologyAbstractFunctional restoration after spinal cord injury (SCI) is one of the most challenging tasks in neurological clinical practice. With a view to exploring effective neurorestorative methods in the acute, subacute, and chronic phases of SCI, &...
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Publication date: Available online 11 November 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Federico Migliorelli, Sara S. De Oliveira, Begoña Martínez de TejadaAbstractBoth caesarean surgery and induction of labour are common practices performed in all labour wards in an attempt to reduce adverse obstetrical and neonatal outcomes. Recent evidence, notably from the ARRIVE Trial, demonstrated that elective induction at 39 weeks reduced the rate of caesarean deliveries and pregnancy-related hypertensive disorders. However, some concerns have to be addressed as the...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Wheat bread is the main foodstuff and supply of dietary energy/protein in most developing countries. Wheat based diets are poor regarding essential amino acid content especially lysine as the first limiting amino acid. Since human body is unable to build lysine, it is necessary to be taken via food and/or supplements. Recommended daily intake of lysine is estimated to be around 30-64 mg/kg body weight. Inadequate intake of lysine results in a syndrome called ‘protein energy malnutrition’ which is suspected to be more prevalent in developing countries. Since lysine is provided by different sources (especially me...
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Conclusion: Dietary intake of high-quality protein or a blend of different proteins will provide all AA to the body. However, studies on protein quality evaluation by DIAAS method are necessary to perform.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Allostasis and allostatic load are new concepts explaining the changes in body stemming from chronic stress. These concepts are explained with the assessment of metabolic, cardiovascular, inflammatory, and neuroendocrine systems. Type 2 Diabetes Mellitus (DM) is a chronic disease with the fluctuations in fasting plasma glucose, and also in other various biomarkers and poses a risk forother chronic diseases. The course and duration of the disease, genetic factors, and environmental factors, including nutrition, aggravate these complications. Allostatic load is a multi-system assessment. Individuals’ compliance with th...
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Conclusion: Further studies are needed to confirm above proposed mechanisms that may explain aspartame- induce immune dysregulation.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Conclusion: The essential oil and hydrosol extract can be used as a potential source of sustainable eco-friendly botanical fungicides to protect stored tomatoes from pathogens, saprophytic fungi causing bio-deterioration to a variety of food commodities.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
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