Bridging translation for acute kidney injury with better pre-clinical modeling of human disease.

Bridging translation for acute kidney injury with better pre-clinical modeling of human disease. Am J Physiol Renal Physiol. 2016 Mar 9;:ajprenal.00552.2015 Authors: Skrypnyk NI, Siskind LJ, Faubel S, de Caestecker MP Abstract The current lack of effective therapeutics for patients with acute kidney injury (AKI) represents an important and unmet medical need. Given the importance of the clinical problem it is time for us to take a few steps back and reexamine current practices. The focus of this review is to explore the extent to which failure of therapeutic translation from animal studies to human studies stems from deficiencies in the pre-clinical models of AKI. We will evaluate whether the pre-clinical models of AKI that are commonly used recapitulate the known pathophysiologies of AKI that are being modeled in humans, focusing on four common scenarios that are studied in clinical therapeutic intervention trials: cardiac surgery-induced AKI; contrast-induced AKI; cisplatin-induced AKI; and sepsis associated AKI. Based on our observations we have identified a number of common limitations in current pre-clinical modeling of AKI that could be addressed. In the long-term we suggest that progress in developing better pre-clinical models of AKI will depend on developing a better understanding of human AKI. To this this end we suggest that there is a need to develop greater in-depth molecular analyses of kidney biopsy tissues coupled wit...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research