Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars.

CONCLUSIONS: The sperm and testicular degeneration of TgHD boars is caused by gain-of-function of the highly expressed mtHtt.
PMID: 26959244 [PubMed - as supplied by publisher]

Source: Neuro-Degenerative Diseases - March 10, 2016 Category: Neurology Authors: Macakova M, Bohuslavova B, Vochozkova P, Pavlok A, Sedlackova M, Vidinska D, Vochyanova K, Liskova I, Valekova I, Baxa M, Ellederova Z, Klima J, Juhas S, Juhasova J, Klouckova J, Haluzik M, Klempir J, Hansikova H, Spacilova J, Collins R, Blumenthal I, Tal Tags: Neurodegener Dis Source Type: research