GI highlights from the literature

Basic scienceInfiltrating lymphocytes initiate necrotising enterocolitis Egan CE, Sodhi CP, Good M, et al. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest Published Online First: 21 Dec 2015. doi: 10.1172/JCI83356 Necrotising enterocolitis (NEC) is a severe inflammatory disease of the GI tract that occurs in premature infants and can result in death. The pathogenesis of NEC includes a perturbation of the intestinal barrier leading to an inflammatory infiltration into the intestinal mucosa of the host resulting in systemic sepsis. Most studies on the pathophysiology of NEC have focused on the intestinal epithelium being responsible for the disease. The role of intestinal inflammatory cells in NEC has not been well studied. Toll-like receptor (TLR) activation is necessary for NEC development, as it is expressed at significantly higher levels on the intestinal epithelium of the premature murine and human gut. It remains to be...
Source: Gut - Category: Gastroenterology Authors: Tags: JournalScan Source Type: research