Gut to lung

Over the last few years, microbiome-focused studies have propelled our understanding of the importance and contribution of several species of gut microbes to immunity and tissue homeostasis.1 Certain microbiota were discovered to essentially shape the intestinal immune system, and changes in the composition of the gut microbiome were found associated with a wide range of diseases, including IBD, metabolic diseases such as diabetes or even neurological disorders like autism.1 These studies laid the foundation for novel therapeutic interventions like microbiome-tailored treatments. As a first, seemingly simple but nevertheless effective step, faecal microbiota transplantation (FMT) is increasingly recognised as a powerful means to treat conditions associated with dysbiosis, most notably Clostridium difficile enteritis.2 In a parallel attempt, the lungs moved into the focus of microbe-interested scientists and clinicians alike. As a result, the lung microbiome as its own unique habitat was explored, ending the...
Source: Gut - Category: Gastroenterology Authors: Tags: Commentary Source Type: research

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Publication date: Available online 6 April 2020Source: Indian Heart JournalAuthor(s): Samit Ghosal, Binayak Sinha, Jignesh Ved, Mansij Biswas
Source: Indian Heart Journal - Category: Cardiology Source Type: research
Purpose of review Hyperlipidemia, hypertension, diabetes and related metabolic disorders increase the risk for cardiovascular disease (CVD). Despite significant progress in the identification of key mechanisms and genetic polymorphisms linked to various CVDs, the rates of CVDs continue to escalate, underscoring the need to evaluate additional mechanisms for more effective therapies. Environment and lifestyle changes can alter epigenetic mechanisms mediated by histone modifications and long noncoding RNAs (lncRNAs) which play important roles in gene regulation. The review summarizes recent findings on the role of epigenet...
Source: Current Opinion in Cardiology - Category: Cardiology Tags: MOLECULAR GENETICS: Edited by Ali J. Marian Source Type: research
The hypothalamus–pituitary–adrenal (HPA) axis acts to release cortisol into the blood stream, as cortisol calls the body into action to combat stress. When high amounts of cortisol interact with the hypothalamus, the HPA axis will slow down its activity. The amygdala detects stress, while the prefrontal cortex regulates our reactions to stress. Source: Bezdek K and Telzer E (2017) Have No Fear, the Brain is Here! How Your Brain Responds to Stress. Front. Young Minds. 5:71. doi: 10.3389/frym.2017.00071 _______ [Editor’s note: Continued from yesterday’s Exploring the human brain and how it responds to...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness #WorldHealthDay brain burnout cognition Cortisol GAS General Adaptation Syndrome homeostasis memory neurobiology neurological exhaustion Stress Source Type: blogs
After 12 weeks of mat Pilates, obese young women with high blood pressure lost body fat and had significantly improved blood pressure compared with those who didn't participate.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news
With millions of people across the U.S. and the world battling COVID-19 infections, many of them struggling to breathe, ventilators have become a top priority for the health-care workers trying desperately to keep patients alive. And those machines, which help patients breathe or breathe for them, are in startlingly short supply. For doctors, resorting to a ventilator is an extreme measure, used when a patient’s lungs cannot supply enough oxygen on their own. Ventilators can also give a patient’s body time to rest when breathing is difficult, and allow doctors to more easily remove lung secretions or deliver me...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized COVID-19 feature Source Type: news
Infertility caused by chemotherapy or radiation treatments negatively impacts patient-survivor quality of life. The only fertility preservation option available to prepubertal boys who are not making sperm is cryopreservation of testicular tissues that contain spermatogonial stem cells (SSCs) with potential to produce sperm and/or restore fertility. SSC transplantation to regenerate spermatogenesis in infertile adult survivors of childhood cancers is a mature technology. However, the number of SSCs obtained in a biopsy of a prepubertal testis may be small. Therefore, methods to expand SSC numbers in culture before transpla...
Source: Urologic Clinics of North America - Category: Urology & Nephrology Authors: Source Type: research
In your opinion, what are the best 10 or 15 programs in the country for IR training? I’m not looking for some silly “top ranked” list, but I thought a list of places that provide well rounded training, have a broad scope (transplant, PAD, aortas) etc would be beneficial to future applicants. From interviews and speaking to attendings and fellows, the places with the most well rounded training seem to be (in no particular order): UCSF Kaiser MD Anderson Rush Northwestern MCW Michigan MIR... Best IR programs for training?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Interventional Radiology Source Type: forums
Condition:   Leukemia Intervention:   Biological: IM19 CAR-T Sponsor:   Beijing Immunochina Medical Science&Technology Co., Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Purpose of review Administration of fecal material into the gastrointestinal tract, termed fecal microbiota transplantation (FMT), is increasingly recognized as an effective treatment option for recurrent Clostridium difficile infection (RCDI). The impact of FMT on host microbial communities and subsequent disease states has also been explored in recent years for conditions as varied as inflammatory bowel disease especially ulcerative colitis, metabolic diseases, such as diabetes, graft-versus-host disease in hematopoietic stem cell transplant recipients, and autism and autism spectrum disorders. The purpose of this arti...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: GASTROENTEROLOGY AND NUTRITION: Edited by Bradley Barth Source Type: research
The gut microbiome—the billions of bacteria that live inside the human digestive tract—is the focus of some of today’s most exciting and compelling medical research. Studies have linked microbiome-related imbalances to health conditions ranging from depression and Parkinson’s disease to heart disease. Some researchers have even started referring to the microbiome as a “forgotten organ” because of the indispensable role it plays in human health. It’s fairly clear that the foods a person eats—or doesn’t eat—can affect the composition of his or her microbiome. Resear...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Research Source Type: news
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