Why Does Aspartame Have a Warning Label?

Discussion Phenylketonuria (PKU) is an autosomal recessive genetic disease. The PAH gene is found on chromosome 12 and has more than 600 mutations associated with it. The incidence varies but PKU is primarily found in Caucasian populations. The PAH gene codes for phenylalanine hydroxylase (PAH) which catalyzes the amino acid phenylalanine (Phe) to tyrosine. PAH uses a cofactor called tetrahydrobiopterin (BH4) in this process. With a deficiency in PAH, Phe accumulates and can cause severe cognitive impairment and global developmental delay, microcephaly, seizures, poor growth and poor skin pigmentation. Tyrosine also decreases and along with it its products of melanin, L-thyroxine and catecholamine neurotransmitters. The exact cause of the PKU clinical problems may be an accumulation of Phe, deficiency in Tyrosine products or another cause but is unknown exactly currently. The mainstay of treatment is a low protein, low phenylalanine diet. Phe is an essential amino acid so some Phe must be supplied in the diet but the amount is highly individualized based on the specific mutation, age and other specific needs of the individual. Specialized formula that is Phe-free is used for infants with children and adults using similar alternative formulas as part of their overall diet. The diet centers on consuming mainly fruits and vegetables. Low protein grains are also used, along with much smaller amounts of whole proteins along with Phe-free formulas. Food products for medical diets ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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Publication date: Available online 12 October 2019Source: Journal of Molecular StructureAuthor(s): Jian Zhong Huo, Xin Shu Li, Jun Dan An, Le Xi Zhang, Yong Li, Gui Xiang Du, Xiang Xia Wu, Yuan Yuan Liu, Bin DingAbstract:Currently the detection of L-phenylalanine is quite important in clinicians, which can be applied as a simple quantitative method to diagnose phenylketonuria, a common inherited disorder of amino acid metabolism. In this work, a novel chiral fluorescence hybrid probe CDs@Eu(D-cam) [CDs = Carbon-dot; D-cam = (1R, 3S)-(+)-Camphoric acid] can be successfully prepared through the encapsulation of the ultra-sma...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 19 October 2019Source: Biological ControlAuthor(s): Qiya Yang, Junwei Diao, Dhanasekaran Solairaj, Ngolong Ngea Guillaume Legrand, Hongyin ZhangAbstractThe present study investigated the effect of ascorbic acid (Vitamin C, VC) at 250μg/mL in the enhancement of biocontrol efficacy of Pichia caribbica against blue mold decay caused by Penicillium expansum on apples. Compared to the performance of the yeast without treatment, P. caribbica induced by 250 μg/mL of VC potentially enhanced biocontrol activity against P. expansum and high growth rate on the apple surface when stored at 20&d...
Source: Biological Control - Category: Biology Source Type: research
CONCLUSIONSĖ NOACs reduced all-cause mortality in patients with or at risk for CAD or PAD, even though they increased the risk of major bleeding. Future studies regarding the best doses of NOACs are warranted. PMID: 31625706 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Publication date: Available online 19 October 2019Source: Comparative Biochemistry and Physiology Part C: Toxicology &PharmacologyAuthor(s): Shouta M.M. Nakayama, Ayuko Morita, Yoshinori Ikenaka, Yusuke K. Kawai, Kensuke P. Watanabe, Chihiro Ishii, Hazuki Mizukawa, Yared B. Yohannes, Keisuke Saito, Yukiko Watanabe, Masaki Ito, Natsuo Ohsawa, Mayumi IshizukaAbstractWorldwide use of anticoagulant rodenticides (ARs) for rodents control has frequently led to secondary poisoning of non-target animals, especially raptors. In order to suggest some factors that may help considering the mechanism of the incidents, this study fo...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - Category: Toxicology Source Type: research
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Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
The vitamin is frequently linked to healthy cognitive aging and adequate levels may help to reduce dementia risk. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Memory subscribers-only Source Type: blogs
In this study, AT1-AAs were detected in the sera of patients with peripheral arterial disease (PAD) and the positive rate was 44.44% vs. 17.46% in non-PAD volunteers. In addition, analysis showed that AT1-AAs level was positively correlated with PAD. To reveal the causal relationship between AT1-AAs and vascular aging, an AT1-AAs-positive rat model was established by active immunization. The carotid pulse wave velocity was higher, and the aortic endothelium-dependent vasodilatation was attenuated significantly in the immunized rats. Morphological staining showed thickening of the aortic wall. Histological examination showe...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The main aim of physical activity in pregnancy is to achieve health-enhancing benefits in a way that is safe, enjoyable and sustainable.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
ConclusionsDifferential disease classification among men who may be recommended to undergo and then consider whether to accept a prostate biopsy leads to inaccurate identification of prostate cancer risk factors. Imputing a man’s prostate cancer status reduces detection bias. Covariate adjustment does not address the problem of outcome misclassification. Cohorts evaluating incident prostate cancer should collect longitudinal screening and biopsy data to adjust for this potential bias.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Discussion Phenylketonuria (PKU) is an autosomal recessive genetic disease. The PAH gene is found on chromosome 12 and has more than 600 mutations associated with it. The incidence varies but PKU is primarily found in Caucasian populations. The PAH gene codes for phenylalanine hydroxylase (PAH) which catalyzes the amino acid phenylalanine (Phe) to tyrosine. PAH uses a cofactor called tetrahydrobiopterin (BH4) in this process. With a deficiency in PAH, Phe accumulates and can cause severe cognitive impairment and global developmental delay, microcephaly, seizures, poor growth and poor skin pigmentation. Tyrosine also decrea...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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