Polarity and asymmetric cell division in the control of lymphocyte fate decisions and function.

Polarity and asymmetric cell division in the control of lymphocyte fate decisions and function.
Curr Opin Immunol. 2016 Mar 2;39:143-149
Authors: Yassin M, Russell SM
Abstract
Polarity is important in several lymphocyte processes including lymphocyte migration, formation of the immunological synapse, and asymmetric cell division (ACD). While lymphocyte migration and immunological synapse formation are relatively well understood, the role of lymphocyte ACD is less clear. Recent advances in measuring polarity enable more robust analyses of asymmetric cell division. Use of these new methods has produced crucial quantification of ACD at precise phases of lymphocyte development and activation. These developments are leading to a better understanding of the drivers of fate choice during lymphocyte activation and provide a context within which to explain the effects of ACD.
PMID: 26945468 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - March 2, 2016 Category: Allergy & Immunology Authors: Yassin M, Russell SM Tags: Curr Opin Immunol Source Type: research