HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from North-East Italy.

HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from North-East Italy. J Med Microbiol. 2016 Mar 3; Authors: Seraceni S, Campisciano G, Contini C, Comar M Abstract Human papillomavirus (HPV) and Chlamydia trachomatis (CT) are pathogens with oncogenic potential associated with persistent infections. Epidemiological data on CT infection status, CT/HPV co-infection and relationship between HPV genotypes in Italian women are only preliminary.The aim of the present study was to characterize the relationship between HPV genotypes and CT in an extending cohort of asymptomatic immunocompetent women from North-East Italy geographic area. A retrospective study was conducted using Luminex technology, on cervical swabs from asymptomatic immunocompetent women, including 921 attending the prevention centre for Cervical Cancer Program and 6214 who had been referred to the Sexually Transmitted Infections Center, with clinical indications of HPV and CT infections, respectively. A quantitative Real time-PCR was performed to assess chronic CT infection by Hsp60 gene expression. The overall prevalence of the investigated pathogens was 39% (359/921) for HPV and 4% (251/6214) for CT. The Hsp60 gene was detected in 57% of the women infected with CT. HPV co-infection was present in 58% of CT infected women. A high prevalence of co-infection was found in women with chronic CT infection (68%) [p= 0.0002], especially...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research