Summaries: International Kidney Cancer Symposium

Conclusion: there is no increased risk of doing the lymph node dissection early on.   Dr. Eggener-CON   Basics Lymph node dissections rarely done, even for large tumors, because there is no proven therapeutic or staging benefit for low risk patients.  A Mayo study revealed no data showing therapeutic benefit in high risk patients.  For clinically node negative high risk patients, there is staging value but no proven therapeutic benefit. Rate of positive nodes is associated with stage and grade; the higher the stage and grade, the more likely there will be positive nodes.  A tumor> 10 cm with sarcomatoid features and tumor necrosis is also associated with positive nodes. Looking at several studies, the percentage of patients that were found to have positive nodes at the time of surgery was relatively small in all but one study.  The 5-year cancer specific survival for these patients was very consistent at 35-39%. According to the National Comprehensive Cancer Network guidelines for kidney cancer, “Regional lymph node dissection is optional but is recommended for patients with adenopathy on preoperative imaging or palpable/visible adenopathy at time of surgery.” Conclusions: Lymph node dissection for patients with clinical node negative T1-T2 disease is proven not to be necessary Lymph node dissection for patients with clinical node negative T3-T4 disease...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news

Related Links:

Publication date: Available online 26 February 2020Source: Meta GeneAuthor(s): Salma Begum Bhyan, YongKiat Wee, Mingyu Luo, Yining Liu, Min Zhao
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
ConclusionsThe microdeletion emphasizes the importance of adequate chromosomal testing in examining the etiology of complex alcohol ‐induced developmental disorders. Furthermore, the genotype‐specific decreased DNA methylation at theIGF2/H19 locus cannot be considered as a biological mark for PAE in adult WBCs.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionOur analysis provided strong evidence to indicate a causal relationship between WC and increased risk of CHD.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionNEAT1 upregulateIGF2 expression through absorbing miR ‐185‐5p to enhances the migration and invasion of colon cancer cells.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionOur results suggest that the combination of altered expression of genes involved in signaling pathways of immune response and apoptosis control may contribute directly to the main characteristics observed in BS, such as recurrent infections, growth failure, and high risk of cancer. Transcriptome studies of other instability syndromes could allow a more accurate analysis of the relevant gene interactions associated with the destabilization of the genome. This is a first description of the profile of differential gene expression related to immunological aspects detected in patients with BS by RNA ‐seq.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: CLINICAL REPORT Source Type: research
ConclusionOur results revealed that mosaicism contributes to a major cause of false negative in NIPS, and highlighted the importance of ultrasound in identifying these false ‐negative results.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Helicobacter pylori is one of the most prevalent infection worldwide. It affects individuals of different age groups. Aging ‐associated risk factors should be considered. Future studies, related to aging andH. pylori infection with extragastric disease can help to provide vivid evidences. AbstractHelicobacter pylori is one of the most prevalent infection worldwide. It affects individuals of different age groups. Elderly people tend to resist eradication treatment and worsening of infection can lead to several gastric and non ‐gastric pathologies. Aging‐associated cellular and molecular alteration can increase the ris...
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: REVIEW ARTICLE Source Type: research
ConclusionIn summary, the above results indicate thatXIST promotes colorectal cancer tumorigenesis by regulating miR ‐93‐5p/HIF ‐1A/AXL signaling pathway, which will supply a novel perspective to diagnose and treat colorectal cancer disease.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 26 February 2020Source: Urology Case ReportsAuthor(s): Tomoko Yonamine, Tadashi Kaname, Yasutsugu Chinen, Kouichi Tamashiro, Noritake Kosuge, Seiichi Saito
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
More News: Alcoholism | Back Pain | Biology | Brain | Brain Cancers | Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer of the Uterus | Cancer Therapy | Carcinoma | Cardiology | Chemotherapy | Child Development | Children | Chronic Pain | Clinical Trials | Colon Cancer | Colorectal Cancer | Congestive Heart Failure | Cough | CT Scan | Dialysis | Eating Disorders & Weight Management | Genetics | Health | Health Management | Heart | Heart Failure | Heart Transplant | Hepatocellular Carcinoma | Hypertension | Infertility | Intensity-Modulated Radiation Therapy | Kidney Cancer | Kidney Transplant | Kidney Transplantation | Laboratory Medicine | Laparoscopy | Liver | Liver Cancer | Liver Transplant | Lung Transplant | Mammography | Men | Molecular Biology | Neoadjuvant Chemotherapy Therapy | Neoadjuvant Radiation Therapy | Neoadjuvant Therapy | Nephrectomy | Neurology | Obesity | Occupational Health | Ovarian Cancer | Ovaries | Pain | Pain Management | Pancreas | Pancreatic Cancer | Papanicolaou (Pap) Smear | Pathology | Pediatrics | PET Scan | Pregnancy | Pregnancy and Breast Cancer | Premature Birth | Pulmonary Thromboembolism | Radiation Therapy | Renal Cell Carcinoma | Reproduction Medicine | Smokers | Statistics | Study | Thrombosis | Thyroid | Thyroid Cancer | Toxicology | Translocation | Transplant Surgery | Transplants | Ultrasound | Urology & Nephrology | Weight Loss | Wilm's Tumor | Women | X-Ray