Summaries: International Kidney Cancer Symposium

Conclusion: there is no increased risk of doing the lymph node dissection early on.   Dr. Eggener-CON   Basics Lymph node dissections rarely done, even for large tumors, because there is no proven therapeutic or staging benefit for low risk patients.  A Mayo study revealed no data showing therapeutic benefit in high risk patients.  For clinically node negative high risk patients, there is staging value but no proven therapeutic benefit. Rate of positive nodes is associated with stage and grade; the higher the stage and grade, the more likely there will be positive nodes.  A tumor> 10 cm with sarcomatoid features and tumor necrosis is also associated with positive nodes. Looking at several studies, the percentage of patients that were found to have positive nodes at the time of surgery was relatively small in all but one study.  The 5-year cancer specific survival for these patients was very consistent at 35-39%. According to the National Comprehensive Cancer Network guidelines for kidney cancer, “Regional lymph node dissection is optional but is recommended for patients with adenopathy on preoperative imaging or palpable/visible adenopathy at time of surgery.” Conclusions: Lymph node dissection for patients with clinical node negative T1-T2 disease is proven not to be necessary Lymph node dissection for patients with clinical node negative T3-T4 disease...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news

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In this study, we tested the hypothesis that transgenerational DEHP exposure alters anxiety-like behavior and neural gene expression in both male and female mice. Pregnant CD-1 mice were orally dosed daily with either tocopherol-stripped corn oil or DEHP (20 or 200 μg/kg/day; 500 or 750 mg/kg/day) from gestational day 10.5 until birth to produce the F1 generation. Females from each generation were bred with untreated, unrelated CD-1 males to produce subsequent generations. Behavior and gene expression assays were performed with adult, intact F3 males and females. Transgenerational DEHP exposure increased time spent ...
Source: Physiology and Behavior - Category: Physiology Source Type: research
Publication date: Available online 23 April 2019Source: Journal of Molecular StructureAuthor(s): Grace Busayo Peleyeju, Talla Emmanuel, Charlotte Mungho Tata, Marthe Carine Djuidje Fotsing, Nicolette Niemann, Lydia Rhyman, Charmaine Arderne, Derek Tantoh Ndinteh, Ponnadurai RamasamiAbstractScandenone (warangalone) is a flavonoid found in Erythrina species and other plant genera. It has been connected with physiological processes in insects, human cells and bacteria. In this article, an overview of the biological importance of this compound is provided. A detailed analysis of its crystal structure and antibacterial properti...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, nonlinear optical responses of olive oil as a pure material and also blended with turmeric powder at different concentrations are demonstrated using z-scan technique. This material is found to be a novel natural nonlinear medium with large nonlinear refractive index. The modified Newton-Raphson method was used to solve the formula obtained from Gaussian Decomposition method for transmission of beam light in z-scan technique. It shows a negative third order nonlinear refractive index (n2) on the order of 10−7cm2/w under irradiation of maximum 50 mw continuous wave (CW) He-Ne laser at 632.8 nm waveleng...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
In conclusion, these data indicate that KIF23 is a potential therapeutic target for gastric cancer treatment. PMID: 31007778 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Conclusions: ICP and IOP have opposing effects on LCD and LC peak strain. While their effects on LCD are equivalent, the effect of IOP on LC peak strain is 3 times larger than that of ICP. The influences of these pressure are dependent on sclera material properties, which might explain the pathogenesis of ocular hypertension and normal-tension glaucoma. PMID: 31007950 [PubMed]
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
Authors: Mitra SR, Tan PY, Amini F Abstract Gene-diet interaction studies have reported that individual variations in phenotypic traits may be due to variations in individual diet. Our study aimed to evaluate (i) the association of ADRB2 rs1042713 with obesity and obesity-related metabolic parameters and (ii) the effect of dietary nutrients on these associations in Malaysian adults. ADRB2 genotyping, dietary, physical activity, anthropometric, and biochemical data were collected from 79 obese and 99 nonobese individuals. Logistic regression revealed no association between ADRB2 rs1042713 and obesity (p=0.725). Howe...
Source: Journal of Nutrition and Metabolism - Category: Nutrition Tags: J Nutr Metab Source Type: research
Publication date: Available online 22 April 2019Source: Life Sciences in Space ResearchAuthor(s): L. Walsh, U. Schneider, A. Fogtman, C. Kausch, S. McKenna-Lawlor, L. Narici, J. Ngo-Anh, G. Reitz, L. Sabatier, G. Santin, L. Sihver, U. Straube, U. Weber, M. DuranteAbstractThe European Space Agency (ESA) is currently expanding its efforts in identifying requirements and promoting research towards optimizing radiation protection of astronauts. Space agencies use common limits for tissue (deterministic) effects on the International Space Station. However, the agencies have in place different career radiation exposure limits (f...
Source: Life Sciences in Space Research - Category: Biology Source Type: research
Publication date: Available online 23 April 2019Source: Life SciencesAuthor(s): Muzammal Hussain, Dickson Adah, Muqddas Tariq, Yongzhi Lu, Jiancun Zhang, Jinsong LiuAbstractThe tumor microenvironment comprises stromal and tumor cells which interact with each other through complex cross-talks that are mediated by a variety of growth factors, cytokines, and chemokines. The chemokine ligand 13 (CXCL13) and its chemokine receptor 5 (CXCR5) are among the key chemotactic factors which play crucial roles in deriving cancer cell biology. CXCL13/CXCR5 signaling axis makes pivotal contributions to the development and progression of ...
Source: Life Sciences - Category: Biology Source Type: research
In this study, the antifungal activity of base analogues, 5-flucytosine (5-FC) and 5-fluorouracil (5-FU), was tested against planktonic cells as well as against mature biofilm.MethodsTests were performed according the EUCAST methodology. Antibiofilm effectiveness of tested drugs was determined by the crystal violet staining method. The cytotoxicity assays was performed according to the ISO 10993-5 norm.Results5-FC and 5-FU were effective against fifteen fluconazole resistant Candida glabrata strains with an average minimal inhibitory concentration (MIC) of 0.152 mg/L and 0.39 mg/L, respectively. Folinic acid (fol...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Conclusion and Recommendations: Consistent condom utilization among HIV clients on ART was low (55.8%). Place of residence and condom use initiation during sexual contact were significantly associated with consistent condom use. It is better to give more emphasis on health education and counseling service about consistent condom use for PLWHA who are on ART during follow-up especially for those who came from rural areas. PMID: 31007955 [PubMed]
Source: AIDS Research and Treatment - Category: Infectious Diseases Tags: AIDS Res Treat Source Type: research
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