Summaries: International Kidney Cancer Symposium

Conclusion: there is no increased risk of doing the lymph node dissection early on.   Dr. Eggener-CON   Basics Lymph node dissections rarely done, even for large tumors, because there is no proven therapeutic or staging benefit for low risk patients.  A Mayo study revealed no data showing therapeutic benefit in high risk patients.  For clinically node negative high risk patients, there is staging value but no proven therapeutic benefit. Rate of positive nodes is associated with stage and grade; the higher the stage and grade, the more likely there will be positive nodes.  A tumor> 10 cm with sarcomatoid features and tumor necrosis is also associated with positive nodes. Looking at several studies, the percentage of patients that were found to have positive nodes at the time of surgery was relatively small in all but one study.  The 5-year cancer specific survival for these patients was very consistent at 35-39%. According to the National Comprehensive Cancer Network guidelines for kidney cancer, “Regional lymph node dissection is optional but is recommended for patients with adenopathy on preoperative imaging or palpable/visible adenopathy at time of surgery.” Conclusions: Lymph node dissection for patients with clinical node negative T1-T2 disease is proven not to be necessary Lymph node dissection for patients with clinical node negative T3-T4 disease...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news

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Medtronic seems to be on a roll when it comes to innovation. The Dublin-based company has received the greenlight from FDA for an expanded indication of the Kyphon HV-R Bone Cement. Under the new indication, Medtronic can market Kyphon for the fixation of pathological fractures of the sacral vertebral body using sacral vertebroplasty or sacroplasty. Sacral insufficiency fractures (SIFs) are a common cause of debilitating back pain. SIFs mimic the symptoms of lumbar spine pathology. Studies show more than two-thirds of patients diagnosed with SIFs aren't able to associate their pain with a traumatic event. As a result, phys...
Source: MDDI - Category: Medical Devices Authors: Tags: Orthopedics Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Signing the divorce papers was probably Charlie’s lowest point.  His wife sitting by his side, occasionally she would swat at the air at some invisible fly buzzing around the room.  There was no fly.  Just the acrid smell of the nursing home, a horrifying mix of sweat, shit, and desperation.  He tried to focus his aged eyes on the legal papers as the tears swirled past his nose and losing traction, fell onto his crusty sweater.  He had no intention of leaving his beloved’s side.  No interest in abandoning his life.  But if he was going to give the level of care neces...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Geriatrics Public Health & Policy Source Type: blogs
CONCLUSION: The consistent application of the existing multimodal treatment options for glioma has led in recent years to improved survival. Areas of important current and future scientific activity include immunotherapy and targeted and combined chemotherapy, as well as altered neurocognition, modern approaches to palliative care, and complementary therapies. PMID: 29914619 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Authors: Roque M, Bianco B, Christofolini DM, Cordts EB, Vilarino FL, Carvalho W, Valle M, Sampaio M, Geber S, Esteves SC, Barbosa CP Abstract Controlled ovarian stimulation (COS) is crucial for optimizing in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) success. Multiple factors influence the ovarian response to COS, making predictions about oocyte yields not so straightforward. As a result, the ovarian response may be poor or suboptimal, or even excessive, all of which have negative consequences for the affected patient. There is a group of patients that present with a suboptimal response to...
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer, Published online: 21 June 2018; doi:10.1038/s41397-018-0030-8Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer
Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSIONS: Use of a surfactant-containing polymeric membrane foam wound dressing with glycerin may have facilitated wound closure in 10 of 13 patients who completed the 12-week study.
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: Features: Clinical Management Extra Source Type: research
This study was aimed to investigate the parasite species and genetic diversity of isolates obtained from CL patients based on the N-acetylglucosamine-1-phosphate transferase (nagt) gene. Methods: Exudate materials were collected from the swollen margin of the skin lesions of the patients suspected with CL who were referred to health centers laboratory of Mehran, Dehloran, Ilam and Malekshahi cities in the Ilam province. Demographic data were collected through a questionnaire. Smears were stained and examined microscopically. In total, 62 parasitologically positive samples were subjected to PCR-RFLP of nagt gene for ide...
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research
15-year-old boy from Florida comes in contact with southern flannel moth caterpillar, immediately getting rash, experiencing "the worst pain he ever felt"
Source: Health News: - Category: Consumer Health News Source Type: news
Well-balanced levels of tyrosine phosphorylation, maintained by the reversible and coordinated actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), are critical for a wide range of cellular processes including growth, di fferentiation, metabolism, migration, and survival. Aberrant tyrosine phosphorylation, as a result of a perturbed balance between the activities of PTKs and PTPs, is linked to the pathogenesis of numerous human diseases, including cancer, suggesting that PTPs may be innovative molecular targets for cancer treatment. Two PTPs that have an important inhibitory role in haemato...
Source: Oncology - Category: Cancer & Oncology Source Type: research
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