Large-scale gene expression profiling reveals physiological response to deletion of chaperone dnaKJ in Escherichia coli

This study is the first to systematically analyze the alterations at the transcriptional level in vivo in deletion of dnaKJ. Fatty acid methyl esters analysis indicated that the amount of unsaturated fatty acid sharply increased and subcellular location prediction analysis showed a marked decrease in transcription of inner-membrane protein genes, which might have triggered the development of aberrant cell shape and susceptibility for some antibiotics in the â–³dnaKJ strain.
Source: Microbiological Research - Category: Infectious Diseases Source Type: research