Immunosuppression in Pancreas Transplantation: What Has Changed in 20 Years?

Abstract Pancreas transplantation offers a functional cure for many patients suffering from diabetes mellitus. Although the outcomes of pancreas transplants were originally plagued with high rates of acute cellular rejection, innovations in immunosuppression regimens over the last two decades have helped steadily improve the graft survival of pancreas transplants. This review surveys the latest trends in immunosuppressive management for pancreas transplant recipients, discussing the controversies and weighing the evidence supporting induction therapy, steroid avoidance/withdrawal, mTOR inhibitors, and new regimens based on costimulatory blockade agents.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Abstract Stem cell therapy is a promising treatment for hepatopathy due to diabetes mellitus (DM); oral resveratrol treatment exhibits protective effects. We investigated whether protective effects could be produced in liver of diabetic rats receiving autologous adipose-derived stem cell transplantation (ADSC) plus oral resveratrol administration. Male rats were divided into four groups: sham group; streptozotocin induced DM group; DM + ADSC group, in which DM rats were treated with 106 stem cells/rat; and DM + R + ADSC group, in which DM rats were treated with ADSC and oral resveratrol. The DM group exhibite...
Source: Biotechnic and Histochemistry - Category: Research Authors: Tags: Biotech Histochem Source Type: research
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Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Clinical Investigation Source Type: research
AbstractAimsTo investigate the long ‐term efficacy and safety of Islet transplantation (ITx) compared to multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII).MethodsAmong 619 patients diagnosed as insulin ‐dependent diabetes mellitus (IDDM) or type 1 diabetes in our hospital, seven patients were selected as the ITx group and 26 age‐matched patients with no endogenous insulin secretion were selected as the MDI/CSII group. HbA1c, AST/ALT and creatinine were assessed retrospectively at 1, 2, 5 and 1 0 years for both groups; serum C‐peptide immunoreactivity (CPR) was assessed for the ITx g...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
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Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 318 Source Type: research
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Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
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Source: ASAIO Journal - Category: Medical Devices Tags: Adult Circulatory Support Source Type: research
Maximizing anti-HBs seroresponsiveness in kidney transplant waitlist patients: 
A tertiary-center perspective
. Clin Nephrol. 2019 Jul 26;: Authors: Udomkarnjananun S, Townamchai N, Wattanatorn S, On-Yim L, Vanichanan J, Jutivorakool K, Avihingsanon Y, Praditpornsilpa K, Eiam-Ong S, Leelahavanichkul A Abstract BACKGROUND: Patients on dialysis are at risk of hepatitis B virus (HBV) infection, and antibodies against the hepatitis B surface antigen (anti-HBs) ≥ 10 IU/L are required. However, a high percentages of HBV vaccine nonresponders have been reported. We aimed to determine the optimal ...
Source: Clinical Nephrology - Category: Urology & Nephrology Authors: Tags: Clin Nephrol Source Type: research
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Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: KIDNEY PANCREAS: Edited by Matthew Cooper Source Type: research
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Source: Memo - Magazine of European Medical Oncology - Category: Cancer & Oncology Source Type: research
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Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
More News: Diabetes | Diabetes Mellitus | Endocrinology | Pancreas | Transplant Surgery | Transplants