Genomic epidemiology of artemisinin resistant malaria

Source: eLife - Category: Biomedical Science Tags: artemisinin drug resistance Genomics and Evolutionary Biology kelch13 malaria Microbiology and Infectious Disease Other plasmodium falciparum Source Type: research

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Abstract Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with over one million deaths each year. Due to old medications and drug resistance worldwide, there is an urgent need for new antiparasitic drugs. 1,3,4-Thiadiazoles have been widely studied for medical applications. The chemical, physical and pharmacokinetic properties recommend 1,3,4-thiadiazole ring as a target in drug development. Many scienti...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Condition:   Malaria,Falciparum Interventions:   Biological: PfSPZ Challenge;   Drug: Sulfadoxine-Pyrimethamine;   Drug: Piperaquine;   Drug: Artemether lumefantrine;   Drug: Primaquine Sponsors:   University of Oxford;   KEMRI-Wellcome Trust Collaborative Research Program;   Sanaria Inc.;   University Hospital Heidelberg;   Kenya Medical Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article will highlight the strategies used to move this critical antimalarial drug through the development pipeline. PMID: 32074317 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Authors: Gao J, Tian Z, Yang X Abstract The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republi...
Source: BioScience Trends - Category: Biomedical Science Tags: Biosci Trends Source Type: research
[Nation] A malaria outbreak has left over 130 people seeking treatment in Bomet County in the last four days, according to local health officials.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Hypophosphatemia is common in severe infections including malaria. Previous studies suggested that serum phosphate concentrations correlate with temperature, but it is unclear whether the type of infection and...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Malaria continues to affect over 200 million individuals every year, especially children in Africa. Rapid and sensitive detection and identification of Plasmodium parasites is crucial for treating patients and mo...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
In malaria-endemic areas, human populations are frequently exposed to immunomodulatory salivary components injected during mosquito blood feeding. The consequences on pathogen-specific immune responses are not...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Plasmodium spp.-infected mosquitos inject sporozoites into the skin of a mammalian host during a blood meal. These enter the host's circulatory system and establish an infection in the liver. After a silent metamorphosis, merozoites invade the blood leading to the symptomatic and transmissible stages of malaria. The silent pre-erythrocytic malaria stage represents a bottleneck in the disease which is ideal to block progression to clinical malaria, through chemotherapeutic and immunoprophylactic interventions. RTS,S/AS01, the only malaria vaccine close to licensure, although with poor efficacy, blocks the sporozoite invasio...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Chen Antimicrobial resistance (AMR) has become a global threat to not only public health impacts but also clinical and economic outcomes. During the past decades, there have been many studies focusing on surveillance, mechanisms, and diagnostics of AMR in infectious diseases but the impacts on public health, clinical and economic outcomes due to emergence of these AMRs are rarely studied and reported. This review was aimed to summarize the findings from published studies to report the outcome impacts due to AMR of malaria, tuberculosis and HIV and briefly discuss the implications for application to other infectious dis...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
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