Spontaneous One-Kidney Rats are More Susceptible to Develop Hypertension by DOCA-NaCl and Subsequent Kidney Injury Compared to Uninephrectomized Rats.

Spontaneous One-Kidney Rats are More Susceptible to Develop Hypertension by DOCA-NaCl and Subsequent Kidney Injury Compared to Uninephrectomized Rats. Am J Physiol Renal Physiol. 2016 Mar 2;:ajprenal.00555.2015 Authors: Wang X, Johnson AC, Sasser JM, Williams JM, Solberg Woods LC, Garrett MR Abstract There is little clinical data of how hypertension may influence individuals with nephron deficiency in the context of being born with a single kidney. We recently developed a new rat model (the HSRA rat) that is born with a single kidney and exhibits progressive kidney injury and decline in kidney function with age. We hypothesized that deoxycorticosterone acetate (DOCA)-salt would induce a greater increase in blood pressure and therefore accelerate progression of kidney injury in rats born with a solitary kidney compared to rats that have undergone unilateral nephrectomy. Time course evaluation of blood pressure, kidney injury, and renal hemodynamics was performed in 6 groups of animals from week 13 -18: (1-2) DOCA+S or Placebo+S (solitary kidney); (3-4) DOCA+C or Placebo+C (two-kidney control); and (5-6) DOCA+UNX8 or Placebo+UNX8 (two-kidney control that have undergone uninephrectomy). DOCA+S treated rats demonstrated a significant (p<0.05) rise in blood pressure (192±4 mmHg), proteinuria (205±31 mg/24hr) and decline in GFR (600+42 µl/min/gKW) relative to DOCA+UNX8 (173±3 mmHg, 76±26 mg/24hr, 963+36 µl/min/gKW) and DOCA+C (154...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research