Neutrophil gelatinase-associated lipocalin (NGAL) as a potential biomarker for early detection of acute renal failure

The objective of this research was to assess the ability of NGAL as a biomarker of acute renal failure by comparing the levels of serum urea and creatinine in rats with induced acute renal failure. Twelve male Wistar rats (Rattus norvegicus), 2 months of age with a body weight (BW) of 150–200 g, were allocated into two groups. Group I (n = 2), as the control group, were injected with sterile distilled water 10 mL/kg BW intramuscularly and group II (n = 10) were injected with 50 % glycerol 10 mL/kg BW intramuscular, the rats in all group had been fasting 12 h before injection. In group II, two rats were selected at each time point (0, 6, 12, 24 and 48 h after injection) bloods collected for analysis of urea and creatinine concentration and identification of NGAL and they were necropsied and the kidney removed for histopathological analysis and NGAL identification. The levels of creatinine and urea were analysed by independent t test. Identification of NGAL was conducted by one-step reverse transcriptase polymerase chain reaction and sequencing. Results showed that the glycerol injection significantly elevated the levels of urea at 6, 12 and 24 h compared to the control group (p 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Authors: Lin WC, Tsai JP, Lai YH, Lin YL, Kuo CH, Wang CH, Hsu BG Abstract Osteoprotegerin (OPG) is a potential biomarker of cardiovascular disease complications and severity. Peripheral arterial disease (PAD) is associated with an increased risk of death in patients on peritoneal dialysis (PD). Therefore, this study aimed to evaluate the relationship between serum OPG levels and PAD by measuring the ankle-brachial index (ABI) of patients on PD. A commercial enzyme-linked immunosorbent assay kit was used to measure OPG values. Left or right ABI values of
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Conclusion: Combined CVVHDF with plasmapheresis is an effective treatment for patients diagnosed with germanium poisoning and associated multiple organ dysfunctions. PMID: 31951756 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Authors: Alexandru S, Ortiz Arduan A, López Picasso M, García-Puente Suarez L, Pampa Saíco SE, Pizarro Sánchez MS, Cannata Ortiz P, Barba Martin R PMID: 31948826 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
We present a review of Melanotan II and the possible effects of this drug on the kidneys by including a case of a renal infarction most likely attributed to Melanotan II. In the mechanism of renal injury with Melanotan II, thrombotic pharmacological influence and possible direct toxic effect on renal parenchyma must be considered.
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
Children with Alport syndrome develop renal failure early in life. Since the safety and efficacy of preemptive nephroprotective therapy are uncertain we conducted a randomized, placebo-controlled, double-blind trial in 14 German sites of pediatric patients with ramipril for three to six years plus six months follow-up to determine these parameters. Pretreated children and those whose parents refused randomization became an open-arm control, which were compared to prospective real-world data from untreated children.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Clinical Trial Source Type: research
Condition:   Patient of Anemia in Chronic Renal Failure With Hemodialysis Interventions:   Drug: RD01;   Drug: Recombinant Human Erythropoiesis Injection (CHO cell);   Drug: placebo Sponsor:   Shengzhen Sciprogen Bio-pharmaceutical Co. Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
SummaryEnd of life is an issue that affects every human being sooner or later. Several aspects at the end of life should not be neglected to achieve good symptom control. Basic knowledge and skills on symptom control and palliative care are important to support patients in this threatening phase of their life. Palliative care should not be provided only at the end of life. The concept of early integration of palliative care is increasingly coming into focus. Nevertheless, at the end of life there are some important facts and issues that should be taken into account. This short article provides a list of ten important facts...
Source: Memo - Magazine of European Medical Oncology - Category: Cancer & Oncology Source Type: research
This study aims to understand the progression of two chronic diseases in the Australian health context. It specifically focuses on the comorbidity progression of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM), as the prevalence of these chronic diseases in Australians is high. A research framework is proposed to understand and represent the progression of CVD in patients with T2DM using graph theory and social network analysis techniques. Two study cohorts (i.e., patients with both T2DM and CVD and patients with only T2DM) were selected from an administrative dataset obtained from an Australi...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Authors: Ma H, Ouyang C, Huang Y, Xing C, Cheng C, Liu W, Yuan D, Zeng M, Yu X, Ren H, Yuan Y, Zhang L, Xu F, Cui Y, Ren W, Huang H, Qian H, Fan B, Wang N Abstract Purpose: Microwave ablation (MWA) is feasible for severe renal secondary hyperparathyroidism (SHPT) and primary hyperparathyroidism (PHPT) patients ineligible for parathyroidectomy (PTX). Here we compared the clinical manifestations and characteristics of parathyroid glands in these two groups, and summarized the techniques, safety and efficacy of MWA.Methods: Baseline clinical characteristics, ablation-related techniques, adverse events/complications, a...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Blackwater fever (BWF), one of the most severe and life-threatening forms of falciparum malaria, is characterized by acute massive intravascular haemolysis, often leading to acute renal failure. Thus far, the ...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
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