Functional genomic investigation of the molecular biological impact of electron beam radiation in lymphoma cells

Conclusion For the first time, 8 MeV pulse EBR induced genomic changes and their consequence in molecular and biological processes were identified in lymphoma cells. The comprehensive investigation of radiation-mediated responses in cancer cells also revealed the potential therapeutic features of EBR. Teaser Molecular genomic effect of 8 MeV electron beam radiation (EBR) in ascites of Dalton's lymphoma was investigated. Integrative functional genomic analyses identified the radiation responsive genes and corresponding biological responses. The activation of p53, PPAR and SMAD signaling pathways along with G2-M phase arrest were observed in irradiated cells. The combinatorial therapeutic possibilities with EBR were also inferred.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research