[Research Article] Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

This study provides proof-of-principle for inducing an MET as differentiation therapy for TICs and uncovers a role for PKA in enforcing and maintaining the epithelial state. Authors: Diwakar R. Pattabiraman, Brian Bierie, Katharina Isabelle Kober, Prathapan Thiru, Jordan A. Krall, Christina Zill, Ferenc Reinhardt, Wai Leong Tam, Robert A. Weinberg
Source: ScienceNOW - Category: Science Authors: Source Type: news