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Research Article Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

This study provides proof-of-principle for inducing an MET as differentiation therapy for TICs and uncovers a role for PKA in enforcing and maintaining the epithelial state. Authors: Diwakar R. Pattabiraman, Brian Bierie, Katharina Isabelle Kober, Prathapan Thiru, Jordan A. Krall, Christina Zill, Ferenc Reinhardt, Wai Leong Tam, Robert A. Weinberg
Source: ScienceNOW - Category: Science Authors: Source Type: news

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Conclusion: Intestinal F. nucleatum is a valuable marker for CRC diagnosis. PMID: 29786050 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Conclusion: MAGE-A1, MAGE-A3, or SSX-2-specific T cell responses were detectable in a subgroup of NPC patients, the frequency and magnitude of which were correlated. PMID: 29786040 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Conclusion: With preoperative chemoradiotherapy, individualized APE may be a relatively safe and feasible approach for low rectal cancer with acceptable oncological outcomes. PMID: 29786037 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
While has hasn ’t been in the news quite as often as his namesake, Dr. Donald “Skip” Trump is celebrating a record-setting fundraising event to benefit a cancer center in Virginia.
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
Cancer quacks frequently characterize conventional treatments for cancer as "cutting, poisoning, and burning." Yet, in Australia a woman with ovarian cancer chose black salve, in essence, "cutting, poisoning, and burning" (but mostly burning and without the cutting) to treat her disease. She died a horrible death. How can black salve still be a thing. The post Helen Lawson and black salve: Cutting, burning, and poisoning “naturally” appeared first on RESPECTFUL INSOLENCE.
Source: Respectful Insolence - Category: Surgery Authors: Tags: Cancer Medicine Pseudoscience Quackery Skepticism/critical thinking alternative cancer cure testimonial Belinda Davies black salve bloodroot Cansema Dennis Wayne Jensen escharotic featured Karen Lawson ovarian cancer Stanisla Source Type: blogs
The objective of The North American Menopause Society (NAMS) and The International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel was to create a point of care algorithm for treating genitourinary syndrome of menopause (GSM) in women with or at high risk for breast cancer. The consensus recommendations will assist healthcare providers in managing GSM with a goal of improving the care and quality of life for these women. The Expert Consensus Panel is comprised of a diverse group of 16 multidisciplinary experts well respected in their fields. The panelists individually conducted an evidence-ba...
Source: Menopause - Category: OBGYN Tags: Consensus Recommendations Source Type: research
Contributors : Michael T Lewis ; Deepika Neelakantan ; Michael U Oliphant ; Xiaomei Zhang ; Lukas M Simon ; David M Henke ; Chad A Shaw ; Meng F Wu ; Susan G Hilsenbeck ; Lisa D White ; Hengbo Zhou ; Heide L FordSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent fate mapping studies concluded that EMT is not required for metastasis of carcinomas. Here we challenge this conclusion by showing that it failed to account for possible crosstalk between EMT and non-EMT cells that promotes dissemination of non-EMT cells. In breast cancer models, EMT cells induce increased metastasis of we...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
AbstractThe cancer stem cell (CSC) hypothesis has been disproved in many cancers. CSCs may exist in blood cancer, while many epithelial cancers may not have CSCs but tumor-initiating cells (TICs). Several independent studies have provided strong evidence for existence of CSCs in brain, skin, and colon cancers (Mani et  al. in Cell 133:704–715,2008, Joseph et  al. in Cancer Cell 13:129–140,2008, Reya et  al. in Nature 414:105–111,2001), while the CSC hypothesis remains controversial (Magee et  al. in Cancer Cell 21:283–296,2012). Liver TICs have bipotential to give rise to two dif...
Source: Hepatology International - Category: Infectious Diseases Source Type: research
Contributors : Mohammed I Khan ; Anna M Czarnecka ; Cezary SzczylikSeries Type : Expression profiling by arrayOrganism : Homo sapiensRecent advancement in cancer research has shown that tumours are highly heterogeneous and multiple phenotypically different cell populations are found in single nodule. Cancer development and tumour growth is driven by specific type of cells - cancer stem cells or tumour initiating cells (CSCs/TICs), which are to be responsible for tumour growth, metastatic spread and drug resistance. This research was designed to verify the presence of tumour initiating cells in renal cancer cell lines. Subs...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
In this study we explored molecular pathways which enable this tumor initiating potential for a cancer cell subset of the transgenic MMTV-PyMT mouse model for metastasizing breast cancer. The cell population, characterized by the marker profile CD24+CD90+CD45-, showed a high tumorigenicity compared to non-CD24+CD90+CD45- cancer cells in colony formation assays, as well as upon orthotopic transplantation into the mammary fat pad of mice. In addition, these orthotopically grown CD24+CD90+CD45- TICs metastasized to the lungs. The transcriptome of TICs freshly isolated from primary tumors by cell sorting was compared with that...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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