Research Article Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

This study provides proof-of-principle for inducing an MET as differentiation therapy for TICs and uncovers a role for PKA in enforcing and maintaining the epithelial state. Authors: Diwakar R. Pattabiraman, Brian Bierie, Katharina Isabelle Kober, Prathapan Thiru, Jordan A. Krall, Christina Zill, Ferenc Reinhardt, Wai Leong Tam, Robert A. Weinberg
Source: ScienceNOW - Category: Science Authors: Source Type: news

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Matt Hancock claims technology is ‘a game-changer’ but critics raise racial bias and ‘fatalism’ concernsThe health secretary is calling for predictive genetic tests for common cancers and heart disease to be rolled out on the NHS without delay.Matt Hancock, speaking at the Royal Society on Wednesday, revealed he recently took a commercial genetic test that showed he is at heightened risk of developing prostate cancer, saying he was shocked by the result. Hancock called for a national debate about the ethical issues around testing for diseases, some of which could not readily be treated.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Genetics Matt Hancock NHS Science UK news Race Health Source Type: news
URMC is only the sixth institution in the country and the only one in New York and the Northeast to receive this accreditation so far.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news
Patient awareness and use of CT colonoscopy have continued to dwindle since...Read more on AuntMinnie.comRelated Reading: Can CTC improve staging for high-risk colon cancer? Calcium scores on CT colonography predict cardiac events Study confirms low rate of incidental findings on CTC CT colonography finds more cancer in seniors Does colonoscopy top CTC for cancer screening?
Source: Headlines - Category: Radiology Source Type: news
Research ArticlesAlessandro Laviano, Luca Di Lazzaro, Angela Koverech,Proceedings of the Nutrition Society,Volume 77 Issue 04, pp 388-393Abstract
Source: Proceedings of the Nutrition Society - Category: Nutrition Source Type: research
Research ArticlesA. Heetun, R. I. Cutress, E. R. Copson,Proceedings of the Nutrition Society,Volume 77 Issue 04, pp 369-381Abstract
Source: Proceedings of the Nutrition Society - Category: Nutrition Source Type: research
Research ArticlesElizabeth Cespedes Feliciano, Wendy Y. Chen,Proceedings of the Nutrition Society,Volume 77 Issue 04, pp 382-387Abstract
Source: Proceedings of the Nutrition Society - Category: Nutrition Source Type: research
Contributors : Michael T Lewis ; Deepika Neelakantan ; Michael U Oliphant ; Xiaomei Zhang ; Lukas M Simon ; David M Henke ; Chad A Shaw ; Meng F Wu ; Susan G Hilsenbeck ; Lisa D White ; Hengbo Zhou ; Heide L FordSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent fate mapping studies concluded that EMT is not required for metastasis of carcinomas. Here we challenge this conclusion by showing that it failed to account for possible crosstalk between EMT and non-EMT cells that promotes dissemination of non-EMT cells. In breast cancer models, EMT cells induce increased metastasis of we...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
AbstractThe cancer stem cell (CSC) hypothesis has been disproved in many cancers. CSCs may exist in blood cancer, while many epithelial cancers may not have CSCs but tumor-initiating cells (TICs). Several independent studies have provided strong evidence for existence of CSCs in brain, skin, and colon cancers (Mani et  al. in Cell 133:704–715,2008, Joseph et  al. in Cancer Cell 13:129–140,2008, Reya et  al. in Nature 414:105–111,2001), while the CSC hypothesis remains controversial (Magee et  al. in Cancer Cell 21:283–296,2012). Liver TICs have bipotential to give rise to two dif...
Source: Hepatology International - Category: Infectious Diseases Source Type: research
Contributors : Mohammed I Khan ; Anna M Czarnecka ; Cezary SzczylikSeries Type : Expression profiling by arrayOrganism : Homo sapiensRecent advancement in cancer research has shown that tumours are highly heterogeneous and multiple phenotypically different cell populations are found in single nodule. Cancer development and tumour growth is driven by specific type of cells - cancer stem cells or tumour initiating cells (CSCs/TICs), which are to be responsible for tumour growth, metastatic spread and drug resistance. This research was designed to verify the presence of tumour initiating cells in renal cancer cell lines. Subs...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
In this study we explored molecular pathways which enable this tumor initiating potential for a cancer cell subset of the transgenic MMTV-PyMT mouse model for metastasizing breast cancer. The cell population, characterized by the marker profile CD24+CD90+CD45-, showed a high tumorigenicity compared to non-CD24+CD90+CD45- cancer cells in colony formation assays, as well as upon orthotopic transplantation into the mammary fat pad of mice. In addition, these orthotopically grown CD24+CD90+CD45- TICs metastasized to the lungs. The transcriptome of TICs freshly isolated from primary tumors by cell sorting was compared with that...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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