Depression medication could help knee osteoarthritis

Researchers at our pain centre are recruiting people to take part in a clinical trial to determine whether duloxetine, a drug normally used to help people with anxiety or depression, can also be effective against the pain of knee osteoarthritis. Current treatments for tackling osteoarthritis are limited. If results from the trial are positive, it could provide a new treatment option for millions of people living with chronic knee pain. Diane Reckziegel, from The University of Nottingham and chief investigator for the study, said: “Duloxetine has already been shown to be effective in relieving different types of chronic pain. However, what we don’t know is how this drug works to reduce pain, and to whom it may be more useful." Understanding the mechanisms of pain relief Before taking the medication patients will undergo MRI scans of their brain. The study will help shed light on how patients experience pain. After the six-week course of medication they'll return for another MRI scan and the effects of the medication will be assessed through questionnaires, imaging and sensory tests.  Diane Reckziegel added: “By comparing the brains of patients with osteoarthritis before and after the treatment we hope to achieve a better understanding of the mechanisms of pain relief. This will help us select patients who might benefit more from duloxetine treatment.” Stephen Simpson, our director of research and programmes, said: "Trials of existing drugs which may also be effec...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news