Timing of predisposing factors is important in necrotic enteritis models.

Timing of predisposing factors is important in necrotic enteritis models.
Avian Pathol. 2016 Feb 29;:1-21
Authors: Van Waeyenberghe L, De Gussem M, Verbeke J, Dewaele I, De Gussem J
Abstract
Since the ban of antimicrobial growth promotors, the importance of necrotic enteritis in broilers increases. Reliable and reproducible infection models are required for pathogenesis studies and product screening. Two major predisposing factors in necrotic enteritis models are fishmeal supplementation to feed and Eimeria infection. However, many unsolved issues regarding these predisposing factors still exist. Therefore, the influence of timepoint of fishmeal administration (onset on day 8 or day 18), timing of coccidiosis challenge (day 15 or day 19) and strain of coccidiosis challenge (field strain vs commercial vaccine) on the induction of necrotic enteritis lesions was investigated. The animals were inoculated with Clostridium perfringens three times per day for four consecutive days (day 17 until day 20) and were scored for the presence of necrotic enteritis on days 22, 23, 24, 25 and 26. Supplementation of the diet with fishmeal from day 8 onwards increased the likelihood of necrotic enteritis compared to supplementation from day 18 onwards. Birds challenged on day 19 with coccidiosis were more likely to have necrotic enteritis on scoring days 23 and 24 compared to birds challenged on day 15. Differences on other scoring days were less prono...

Source: Avian Pathology - February 29, 2016 Category: Pathology Authors: Van Waeyenberghe L, De Gussem M, Verbeke J, Dewaele I, De Gussem J Tags: Avian Pathol Source Type: research