Effects of Implant-Associated Osteomyelitis on Cefuroxime Bone Pharmacokinetics: Assessment in a Porcine Model
Conclusions:
Cefuroxime penetration into infected cancellous bone was incomplete but comparable with that in healthy bone. The destructive bone processes associated with acute osteomyelitis reduced cefuroxime penetration further.
Clinical Relevance:
These findings support the general clinical perception that fast diagnosis and early initiation of antibiotics before the development of implant-associated cavities is important in nonsurgical management of acute osteomyelitis.
Source: JBJS - Category: Orthopaedics Authors: Tottrup, M., Bue, M., Koch, J., Jensen, L. K., Hanberg, P., Aalbaek, B., Fuursted, K., Jensen, H. E., Soballe, K. Tags: Basic Science Scientific Articles Source Type: research
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