CD146 promotes metastasis and predicts poor prognosis of hepatocellular carcinoma.

CONCLUSIONS: CD146 promoted metastasis of HCC cells and predicted poor prognosis of HCC patients. CD146 induced EMT, and IL-8 upregulation and STAT1 downregulation may be the potential underlying mechanism. The exact mechanism still needs further investigation. PMID: 26928402 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26928402?dopt=Abstract

Source: Clinical Prostate Cancer - March 3, 2016 Category: Cancer & Oncology Authors: Jiang G, Zhang L, Zhu Q, Bai D, Zhang C, Wang X Tags: J Exp Clin Cancer Res Source Type: research