Testosterone Replacement Therapy and the Cardiovascular System

Abstract As testosterone replacement therapy (TRT) has emerged as a commonly prescribed therapy for symptomatic low testosterone, conflicting data have been reported in terms of both its efficacy and potential adverse outcomes. One of the most controversial associations has been that of TRT and cardiovascular morbidity and mortality. This review briefly provides background on the history of TRT, the indications for TRT, and the data behind TRT for symptomatic low testosterone. It then specifically delves into the rather limited data for cardiovascular outcomes of those with low endogenous testosterone and those who receive TRT. The available body of literature strongly suggests that more work, by way of clinical trials, needs to be done to better understand the impact of testosterone and TRT on the cardiovascular system.
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research

Related Links:

Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Genes, Vol. 10, Pages 713: The Global Prader–Willi Syndrome Registry: Development, Launch, and Early Demographics Genes doi: 10.3390/genes10090713 Authors: Jessica Bohonowych Jennifer Miller Shawn E. McCandless Theresa V. Strong Advances in technologies offer new opportunities to collect and integrate data from a broad range of sources to advance the understanding of rare diseases and support the development of new treatments. Prader–Willi syndrome (PWS) is a rare, complex neurodevelopmental disorder, which has a variable and incompletely understood natural history. PWS is characterized by ear...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
ConclusionsOur cohort demonstrated an increased incidence of hypophysitis with anti ‐PD1/anti‐PDL1 in contrast to the rarity of primary thyroid dysfunction with anti‐CTLA4 treatment. These results could be attributed to genetic/ethnic differences. Sequential treatment is, for the first time to our knowledge, reported to increase the risk of developing hypophysitis to a level as high as that of combination therapy.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
THURSDAY, Sept. 12, 2019 -- More men with long-term opioid use are screened for low testosterone than men taking opioids for a short period of time; however, given the known link between opioid use and low testosterone, these rates were still lower...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Title: Low Testosterone (Low-T)Category: Diseases and ConditionsCreated: 12/14/2009 12:00:00 AMLast Editorial Review: 9/11/2019 12:00:00 AM
Source: MedicineNet Mens Health General - Category: Primary Care Source Type: news
Abstract This Position Statement has been endorsed by the International Menopause Society, The Endocrine Society, The European Menopause and Andropause Society, The International Society for Sexual Medicine, The International Society for the Study of Women's Sexual Health, The North American Menopause Society, The Federacion Latinoamericana de Sociedades de Climaterio y Menopausia, The Royal College of Obstetricians and Gynecologists, The International Society of Endocrinology, The Endocrine Society of Australia, and The Royal Australian and New Zealand College of Obstetricians and Gynecologists. PMID: 314988...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
AbstractPurpose of ReviewThis review describes case reports for patients with kratom-associated adverse events in order to assist clinicians with patient management. A stepwise approach is proposed for assessing active kratom users as well as considerations for the management of toxicities or withdrawal.Recent FindingsMultiple in vitro and in vivo studies illustrate the pharmacologic and toxicologic effects of kratom extract. No randomized controlled trials in humans exist that assess the safety and efficacy of the substance. Cross-sectional surveys from active users and reports from poison control centers have shown acute...
Source: Current Emergency and Hospital Medicine Reports - Category: Emergency Medicine Source Type: research
ConclusionsFindings suggest that local organizational factors play an important role in influencing prescribing. Sites have the potential to transform their utilization patterns by providing access to specialty care expertise, an electronic health record-based system to facilitate guideline-concordant prescribing, well-defined dissemination processes for information, guidance from multiple sources, and clarity regarding best practices for prescribing.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
ConclusionsWhile recent research has provided new insights into mechanistic and clinical aspects of diabesity ‐associated LOH, more evidence from well‐designed large trials is needed to guide the optimal clinical approach to such men.
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Review Article Source Type: research
Researchers from the University of Texas Medical Branch have found a low rate of screening and treatment for low testosterone levels in men taking opioids, in a study published inMayo Clinic Proceedings: Innovations, Quality& Outcomes.News Medical
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
More News: Cardiology | Cardiovascular | Clinical Trials | Heart | Low Testosterone