Inferring the Effects of Cancer Treatment: Divergent Results From Early Breast Cancer Trialists Collaborative Group Meta-Analyses of Randomized Trials and Observational Data From SEER Registries [Breast Cancer]

Conclusion This study of mortality after radiotherapy for breast cancer found strikingly divergent results between the Early Breast Cancer Trialists’ Collaborative Group meta-analyses of randomized data and the SEER observational data, even when efforts had been made to remove confounding and selection biases. Nonrandomized comparisons are liable to provide misleading estimates of treatment effects. Therefore, they need careful justification every time they are used.
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Radiation, Clinical Trials, Population and observational studies (SEER, WHI observational, etc.), Radiation Oncology, Statistics in Oncology Breast Cancer Source Type: research