Metastatic colon neuroendocrine carcinoma found in a patient with ulcerative colitis during annual endoscopic surveillance

A 70-year-old man with a 12-year history of ulcerative colitis (UC) underwent a colonoscopy including chromoendoscopy 1 year earlier. Mild proctosigmoiditis was observed with no malignant findings. Surveillance colonoscopy 12 months later revealed an elevated lesion 15 mm in diameter with a central depression in the sigmoid colon (A). CT scan revealed multiple metastatic lesions in the liver, yet no lesion was found on a CT scan performed 4 months before the last colonoscopy (B). Tumor biopsy specimens from both the colon and liver showed solid/nesting poorly differentiated cells with hyperchromatic nuclei and scanty cytoplasm (C, colon; D, liver).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: At the focal point Source Type: research

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Background: Many of those aging with HIV suffer from distal neuropathic pain (DNP) due to HIV-associated sensory neuropathy (HIV-SN). Prior studies have linked chronic pain conditions to a variant of the catechol-O-methyltransferase (COMT), Val158Met. This variant confers reduced enzymatic activity and results in higher synaptic dopamine levels. Here we examined the role of Val158Met as a predictor of DNP in HIV-SN. Methods: In 1044 HIV-infected individuals enrolled in CNS HIV Antiretroviral Therapy Effects Research, an observational study across six US institutions, we characterized the relationship between Val158Met...
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Conclusion: Neuropsychiatric illness increased odds of being frail on a predominantly physical/motoric measure, but only when symptomatic. Lack of association with asymptomatic impairment may reflect the importance of functional limitation to frailty, or possibly a unique resilience phenotype. Understanding why sex and symptomatic neuropsychiatric illness are associated with frailty will be important in managing HIV-associated morbidity in aging populations.
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
ConclusionIn late stages, patients with chemotherapy had lower recurrence rate and favorable OS as compared to patients not taking chemotherapy, which was the benefit of postoperative adjuvant chemotherapy, and chemotherapy might be strongly considered in late stage EA.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
In this study, we identified a novel antibacterial peptide, RIVELTLPRVSVRL-NH2 (named CF-14), derived from the epidermal mucus of catfish and characterized its antimicrobial activity. Analysis of antimicrobial activity and hemolytic activity of CF-14 revealed broad spectrum, high levels of antimicrobial activity and low toxicity to eukaryotic cells. CF-14 remained stable at pH values ranging from 4.0 to 12.0 and remained bioactive when exposed to high temperature. CD analysis indicated that CF-14 forms a random coil in PBS buffer and an α-helical conformation in the membrane-mimetic 2.5% SDS micelle. Additionally, th...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: 15 October 2019Source: Journal of Non-Crystalline Solids, Volume 522Author(s): G.M. Aparicio, R.A. Vargas, P.R. BuenoAbstractNanocomposite polymer membranes based on PVA/TiO2 were prepared by a solution casting method. Glutaraldehyde solution (GA) was used as linking agent to improve the chemical, thermal and physical properties of the membranes. The degree of cross-linking was varied by changing the reaction time. The phase behavior of the membranes was examined by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). High resolution SEM micrographs show that the TiO2 nanoparticle...
Source: Journal of Non Crystalline Solids - Category: Chemistry Source Type: research
Publication date: Available online 13 July 2019Source: Journal of Environmental Chemical EngineeringAuthor(s): María Laura Godoy, Ezequiel David Banús, Eduardo Ernesto Miró, Viviana Guadalupe MiltAbstractStacked stainless steel wire mesh monoliths were developed as supports for Pt/Co,Ce catalysts for diesel exhaust treatment. After the calcination of the metal structures at 900 °C, a Co,Ce layer was deposited over the meshes by means of an equimolar suspension of Co3O4 and CeO2 nanoparticles, followed by the incorporation of 1 wt.% Pt. Also, a double bed catalyst configuration was studied...
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
Publication date: Available online 13 July 2019Source: Journal of Analytical and Applied PyrolysisAuthor(s): Dingcheng Liang, Qiang Xie, Zheng Wei, Chaoran Wan, Guangsheng Li, Junya CaoAbstractThe transformation of alkali and alkaline earth metals (AAEMs) in Zhundong coal during pyrolysis in an entrained flow bed reactor was elucidated, which provides theoretical guidance for selecting suitable processing technology for Zhundong coal. A typical coal was sampled, and a series of pyrolysis experiments with gradual and small increments in temperature was performed using an entrained flow bed reactor. Chars from pyrolysis at d...
Source: Journal of Analytical and Applied Pyrolysis - Category: Chemistry Source Type: research
In this study, the ablation characteristics of carbon/phenolic composites were evaluated using X-ray microtomography. The ablation tests of carbon/phenolic composites were performed using a 0.4 MW arc-heated wind tunnel, and the composite samples were scanned using micro-computed tomography (Micro-CT) to analyze the ablation characteristics according to the duration of the ablation test. Through calibration of the scanned raw images, ∼2,000 cross-sectional images were generated with micrometer level intervals. Using these obtained cross-sectional images, the porosity and density distributions in the longitudinal dire...
Source: Composites Science and Technology - Category: Science Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
A 70-year-old man with a 12-year history of ulcerative colitis (UC) underwent a colonoscopy including chromoendoscopy 1 year earlier. Mild proctosigmoiditis was observed with no malignant findings. Surveillance colonoscopy 12 months later revealed an elevated lesion 15  mm in diameter with a central depression in the sigmoid colon (A). CT scan revealed multiple metastatic lesions in the liver, yet no lesion was found on a CT scan performed 4 months before the last colonoscopy (B). Tumor biopsy specimens from both the colon and liver showed solid/nesting poorly di fferentiated cells with hyperchromatic nuclei and scant...
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: At the focal point Source Type: research
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