Abstract P5-05-06: Cobalamin metabolism in breast cancer

Conclusion:The Cbl metabolic pathway is upregulated within aggressive breast malignancies and can be biochemically targeted by a simple pulse-chase technique in vivo. The definitive mechanisms underpinning the up-regulated mitochondrial metabolism of Cbl within human breast tumors and the PC methodology remain to be elucidated. Further investigation of Cbl metabolism within benign and malignant breast tissue could potentially yield new molecular targets to detect and treat aggressive breast tumors.Citation Format: Collins DA. Cobalamin metabolism in breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-05-06.
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research

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Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Increased rates of locoregional recurrence are observed in patients with basal-like breast cancer (BC) despite the use of radiation therapy (RT); therefore, approaches that result in radiosensitization of basal-like BC are critically needed. Using patients’ tumor gene expression data from 4 independent data sets, we correlated gene expression with recurrence to find genes significantly correlated with early recurrence after RT. The highest-ranked gene, TTK, was most highly expressed in basal-like BC across multiple data sets. Inhibition of TTK by both genetic and pharmacologic methods enhanced radiosensitivity in mul...
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Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
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Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
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Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
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Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
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