Abstract P4-14-12: Interim results from the first open-label, multicenter, phase IIIb study investigating the combination of pertuzumab with subcutaneous trastuzumab and a taxane in patients with HER2-positive metastatic breast cancer (SAPPHIRE)

Conclusion: We report the first data on the use of pertuzumab with SC trastuzumab. The observed safety profile is consistent with that previously reported in the CLEOPATRA (Baselga, et al. NEJM 2012;366:109-19), PERUSE [Bachelot, et al. JCO 2014;32:5s(abstr#548)] and HannaH (Ismael, et al. Lancet Oncol 2012;13:869-78) studies, with no unexpected safety signals. Clinical trial information:NCT02019277.Citation Format: Woodward N, De Boer RH, Redfern A, White M, Young J, Truman M, Beith J. Interim results from the first open-label, multicenter, phase IIIb study investigating the combination of pertuzumab with subcutaneous trastuzumab and a taxane in patients with HER2-positive metastatic breast cancer (SAPPHIRE). [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-14-12.

Source: Cancer Research - February 18, 2016 Category: Cancer & Oncology Authors: Woodward, N., De Boer, R., Redfern, A., White, M., Young, J., Truman, M., Beith, J. Tags: Poster Session Abstracts Source Type: research