Abstract P2-02-09: Obesity associated factors are inversely associated with circulating tumor cells in metastatic breast cancer

Conclusions: Obesity associated metabolic factors including weight, BMI, insulin, HOMA and leptin were inversely associated (and adiponectin and height positively associated) with CTC counts. These patterns are consistent with weight loss and/or cachexia in women with elevated CTC counts who have higher disease burden. Additional analyses are underway to further characterize these associations and include assessment of serum albumin, free fatty acids, creatine kinase and hepcidin.Citation Format: Dowling RJO, Chang MC, Lohmann AE, Ennis M, Amir E, Elser C, Brezden-Masley C, Vandenberg T, Lee E, Fazaee K, Stambolic V, Goodwin PJ. Obesity associated factors are inversely associated with circulating tumor cells in metastatic breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P2-02-09.

Source: Cancer Research - February 18, 2016 Category: Cancer & Oncology Authors: Dowling, R., Chang, M., Lohmann, A., Ennis, M., Amir, E., Elser, C., Brezden-Masley, C., Vandenberg, T., Lee, E., Fazaee, K., Stambolic, V., Goodwin, P. Tags: Poster Session Abstracts Source Type: research