Molecular Fluorescence Endoscopy Targeting Vascular Endothelial Growth Factor A for Improved Colorectal Polyp Detection

Conclusion: VEGF-A is a promising target for molecular fluorescence endoscopy because it showed a high protein expression, especially in sessile serrated adenomas/polyps and Lynch syndrome. We demonstrated the feasibility to visualize small tumors in real time during colonoscopy using a NIR fluorescence endoscopy platform, providing the endoscopist a wide-field red-flag technique for adenoma detection. Clinical studies are currently being performed in order to provide in-human evaluation of our approach.

Source: Journal of Nuclear Medicine - March 1, 2016 Category: Nuclear Medicine Authors: Tjalma, J. J., Garcia-Allende, P. B., Hartmans, E., Terwisscha van Scheltinga, A. G., Boersma-van Ek, W., Glatz, J., Koch, M., van Herwaarden, Y. J., Bisseling, T. M., Nagtegaal, I. D., Timmer-Bosscha, H., Koornstra, J. J., Karrenbeld, A., Kleibeuker, J. Tags: Basic Science Investigations Source Type: research