Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner.

CONCLUSIONS: We showed that exenatide skewed the macrophages phenotype toward anti-inflammatory phenotype and this effect is predominantly attributable to protein kinase A and to a less extent to B/Akt activation. PMID: 26922535 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26922535?dopt=Abstract

Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Bułdak Ł, Machnik G, Bułdak RJ, Łabuzek K, Bołdys A, Belowski D, Basiak M, Okopień B Tags: Pharmacol Rep Source Type: research