Epicutaneous (EC) immunization with type II collagen (COLL II) induces CD4(+) CD8(+) T suppressor cells that protect from collagen-induced arthritis (CIA).

CONCLUSION: Maneuver of EC immunization with a protein antigen that induces suppressor cells to inhibit inflammatory responses may become an attractive, noninvasive, needle-free therapeutic method for different clinical situations.
PMID: 26922557 [PubMed - as supplied by publisher]

Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Marcińska K, Majewska-Szczepanik M, Lazar A, Kowalczyk P, Biała D, Woźniak D, Szczepanik M Tags: Pharmacol Rep Source Type: research