Association of Resting Metabolism in the Fear Neural Network With Extinction Recall Activations and Clinical Measures in Trauma-Exposed Individuals.

CONCLUSIONS: Resting metabolism in the fear circuitry correlated with functioning, PTSD symptoms, and extinction recall activations, further supporting the relevance of this network to the pathophysiology of PTSD. The study findings also highlight the fact that chronic dysfunction in the amygdala and hippocampus is demonstrable in PTSD and other trauma-exposed individuals, even without exposure to an evocative stimulus.
PMID: 26917165 [PubMed - as supplied by publisher]

Source: The American Journal of Psychiatry - February 26, 2016 Category: Psychiatry Authors: Marin MF, Song H, VanElzakker MB, Staples-Bradley LK, Linnman C, Pace-Schott EF, Lasko NB, Shin LM, Milad MR Tags: Am J Psychiatry Source Type: research