First Uterus Transplant in U.S. Bolsters Pregnancy Hopes of Many

Surgeons at the Cleveland Clinic have performed the nation’s first such procedure. The goal: to help women who lack a uterus have babies.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Uterus Women and Girls Transplants Infertility Pregnancy and Childbirth Cleveland Clinic Source Type: news

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We describe, to our knowledge, the first case worldwide of livebirth following uterine transplantation from a deceased donor in a patient with MRKH syndrome. The results establish proof-of-concept for treating uterine infertility by transplantation from a deceased donor, opening a path to healthy pregnancy for all women with uterine factor infertility, without need of living donors or live donor surgery.FundingFundação de Amparo à Pesquisa do Estado de São Paulo and Hospital das Clínicas, University of São Paulo, Brazil.
Source: The Lancet - Category: General Medicine Source Type: research
A novel transplantation procedure may help more infertile women become pregnant.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Uterus Transplants Pregnancy and Childbirth Infertility Lancet, The (Journal) Brazil Source Type: news
The world’s first baby born by a uterus transplant from a deceased donor is healthy and nearing her first birthday, according to a new case study published Tuesday in the Lancet. Uterus transplants have become more common in recent years, resulting in 11 live births around the world. But all of the other successful deliveries so far have been made possible by living donors — often women who opt to donate their uterus to a close friend or family member without one. The birth resulting from the case detailed in the Lancet, which took place at Brazil’s Hospital das Clínicas last December, is both the first...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized fertility healthytime Source Type: news
Conclusion: This study confirms a low pregnancy rate in survivors of childhood HSCT. Natural conception was possible when patients are conditioned without TBI. After TBI, pregnancy assisted fertilization techniques may increase pregnancy rate. The number of live births and complications indicate the need to advise survivors of childhood HSCT about the potential risks and outcome of pregnancy and advise them appropiately.DisclosuresBader: Cellgene: Consultancy; Neovii: Research Funding; Medac: Patents &Royalties, Research Funding; Riemser: Research Funding; Novartis: Consultancy, Speakers Bureau.
Source: Blood - Category: Hematology Authors: Tags: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Poster II Source Type: research
Background.Infertility is common after HCT predominantly as a result of the chemoradiotherapy used in conditioning. Patients are increasingly encouraged to store gametes, tissue or embryos before transplant for use after their potentially sterilising treatment. Furthermore, some patients do retain or recover fertility and conceive naturally.Methods:We sent questionnaires to 602 EBMT centers requesting retrospective details of number of pregnancies following either allogeneic or autologous HCT, use of artificial reproductive techniques (ART) and pregnancy outcome for all patients treated between 1995-2015.Results:47 centers...
Source: Blood - Category: Hematology Authors: Tags: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Poster I Source Type: research
Purpose of review The current review gives an updated synopsis of all cases of uterus transplantation (UTx) that has been published and technical details about surgery. The live births that so far have been reported are described regarding pregnancy and outcome. In addition, the review highlights some specific areas of live donor UTx, deceased donor UTx and UTx in general that need further research for clarification/optimization. It is predicted that the clinical field of UTx will expand rapidly and recommendations for a scientific development of the UTx field are presented. Recent findings The first successful UTx wa...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: COMPOSITE TISSUE TRANSPLANTATION: Edited by Gerald Brandacher Source Type: research
The decidua is a transient uterine tissue shared by mammals with hemochorial placenta and is essential for pregnancy. Hoxa11 knockout (KO) mice are infertile having endometrial stromal cell defects resulting in lack of decidualization and implantation failure. Since bone marrow (BM)-derived cells (BMDC) were shown to differentiate into non-hematopoietic endometrial cells, we hypothesized that bone marrow transplantation from wild-type (WT) mice may rescue uterine defects in Hoxa11 KO mice.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Oral session Source Type: research
uml;m M Abstract PURPOSE OF REVIEW: The current review gives an updated synopsis of all cases of uterus transplantation (UTx) that has been published and technical details about surgery. The live births that so far have been reported are described regarding pregnancy and outcome. In addition, the review highlights some specific areas of live donor UTx, deceased donor UTx and UTx in general that need further research for clarification/optimization. It is predicted that the clinical field of UTx will expand rapidly and recommendations for a scientific development of the UTx field are presented. RECENT FINDINGS:...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
There is rapidly growing interest in uterine transplantation for the management of uterine factor infertility (UFI). Recent experimental procedures have demonstrated that women with congenital or acquired absence of a uterus can become pregnant and give birth to a child after a successful uterine transplant, with the first birth occurring in 2015 [1]. The procedure was once considered only in theory, remaining a unique intersection of reproductive and transplant medicine that had never been undertaken.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Editorial Source Type: research
To regenerate functional endometrium tissue using “cell sheet” techniques as a regenerative medicine approach to address endometrial disorders causing female factor infertility.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Original article Source Type: research
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