Medical News Today: First uterus transplant in US offers hope of pregnancy for women with UFI
The first uterus transplant has taken place in the US, which could lead to successful pregnancies in future for women who cannot conceive due to uterine factor infertility.
This study presents a summary of the investigations that indicate the key role of stem cell therapy in regeneration and renovation of defective parts.
Although cancer remains a critical health concern, significant medical advances in cancer detection and treatment have improved survival rates for patients. In children receiving total body radiation (TBI), bone-marrow transplant (BMT), or cyclophosphamide equivalent dose (CED) of>4,000mg/m2, the risk of infertility is significant. The National Physicians Cooperative (NPC) has published site-specific articles compiling data regarding use of cryopreserved tissue, return of endocrine function, and pregnancy outcomes, however no comprehensive review has been conducted.
This study presents a summary of the investigations that indicate the key role of stem cell therapy in regeneration and renovation of defective parts. PMID: 29571018 [PubMed - as supplied by publisher]
Hormonal changes, in either men or women experiencing chronic kidney disease (CKD), cause a decreased libido, erectile dysfunction, dysmenorrhea and ovarian dysfunction, all of which may contribute to infertility. Patients could rapidly restore endocrines and sexual function after a successful renal transplantation (RTx), which may assist in achieving a successful pregnancy. However, the fetus will be exposed to the immunosuppressive agents passed on from the female recipients, which may be another potential factor leading to a poor fetal outcome.
Kidney transplantation (KTx) is the treatment of choice in patients with end-stage renal failure. Among various medical issues in female graft recipients, the need for maternity can become an overriding one. Gonadal dysfunction usually resolves within 6 months after transplantation. However, the prevalence of infertility is similar to this in the general population.
A second woman in the U.S. born without a uterus has given birth to a baby, thanks to a uterus transplant. The birth took place at Baylor University Medical Center at Dallas, a part of Baylor Scott &White, which performed the first birth via uterus transplant late last year. The baby, born in February, is a girl. The hospital is not revealing the identity of the mother, but says the pregnancy and birth were uncomplicated. The birth is the second in the hospital’s ongoing uterus transplant clinical trial. The women in the trial have absolute uterine factor infertility (AUI), which means their uterus is nonfunction...
Uterine factor infertility (UFI) affects thousands of women. UFI may be caused by congenital absence of the uterus (Mayer-Rokitansky-Kuster-Hauser or MRKH syndrome), iatrogenic removal of the uterus, or women who have uteri that are in situ but have been damaged by infection of surgical instrumentation (1). Despite advances in assisted reproductive technologies, women with UFI cannot achieve pregnancy, which has led to the development of uterine transplantation (2). In the event that a patient with UFI is approved to undergo uterine transplantation, IVF must first be performed to assure the availability of embryos for tran...
The video by Fornalik and Fornalik on robotic-assisted uterus transplantation (1) is of interest in the developing field of uterus transplantation (UTx). It relates to infertility treatment of women with absolute uterine factor infertility, with either uterine absence (congenital/surgical) or abnormalities (anatomic/functional) that impede implantation of an embryo or completion of a pregnancy. This condition has been untreatable until recently; in our report of a birth occurring in 2014 (2), UTx proved to be an effective treatment.
For women with uterine factor infertility who want to be mothers, the calculus has always been heartbreakingly simple: No uterus means no pregnancy. The equation changed drastically in 2014, when Swedish doctors delivered a healthy 3.9-pound baby that was the result of a successful uterus transplant. Now, doctors at Baylor University say a woman born […]Related:A model tattooed her eyeball purple. She now could lose her eye.A man collapsed with ‘Do Not Resuscitate’ tattooed on his chest. Doctors didn’t know what to do.A man claims he went down a ‘Raging Rapids’ ride — and came out...
A woman born without a uterus had one transplanted from a live donor, and gave birth to a healthy son, at Baylor University Medical Center in Dallas.