Susceptibility to West Nile Virus Infection

Viral Immunology Mar 2014, Vol. 27, No. 2: 31-31.
Source: Viral Immunology - Category: Allergy & Immunology Tags: article Source Type: research

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WEST NILE VIRUS INFECTION WITH NEUROLOGICAL DISORDERS: A CASE REPORT AND A BRIEF REVIEW OF THE SITUATION IN BULGARIA. Acta Clin Croat. 2019 Sep;58(3):546-549 Authors: Baymakova M, Christova I, Panayotova E, Trifonova I, Chobanov A, Daskalov I, Popov GT, Plochev K Abstract A case of a 66-year-old man with West Nile neuroinvassive disease manifested with fever, weakness, fatigue, consciousness disorders and underlying diabetes mellitus type 2 and cardiovascular diseases is presented. Laboratory data showed elevated erythrocyte sedimentation rate and fibrinogen. Serological tests revealed West Nile virus ...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
(Hokkaido University) West Nile virus (WNV) inhibits autophagy -- an essential system that digests or removes cellular constituents such as proteins -- to induce the aggregation of proteins in infected cells, triggering cell death and brain inflammation (encephalitis), according to Hokkaido University researchers.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense against WN virus, and neutralizing antibodies, which are directed against the viral glycoprotein E, are an accepted correlate of protection. For the efficient production of these antibodies, B cells interact directly with CD4 helper T cells that recognize peptides from E or the two other structural proteins (capsid-C and membrane-prM/M) of the virus. However, the specific protein sites yielding such helper epitopes remain unknown. Here, we explored ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Yes. However, very probably not because of the novel coronavirus that has appeared in China. This seems to be front page headlines in every media outlet on the planet, and  the World Health Organization has convened a meeting to decide whether to declare an official Global Health Emergency.This sort of flapdoodle happens every time a novel pathogen appears. Back when I lived in the Hub of the Universe a mosquito-borne disease called West Nile virus appeared (having formerly been large confined to, yes, west of the Nile). For weeks, every time a new case was identified it would be on the front page of the Boston Globe....
Source: Stayin' Alive - Category: American Health Source Type: blogs
AbstractGuillain –Barré syndrome (GBS) is an acute-onset, immune-mediated polyradiculoneuropathy, often precipitated by an antecedent infection. An association of GBS with vector-borne viral infections has been suggested, with evidence for the involvement of Zika, Dengue, Chikungunya and West Nile virus (WNV). Th is prospective case–control study was conducted to identify vector-borne viral infections in GBS. Thirteen individuals newly diagnosed as GBS were enrolled. Disease severity, prognostic factors and nerve conduction patterns were assessed. Eleven individuals with non-infectious conditions requiri...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
eacute;ter Kertész Anett Kepner Máté Martina Tamás Süli Zsófia Lanszki Gábor Endre Tóth Anett Kuczmog Balázs Somogyi Ferenc Jakab Gábor Kemenesi The West Nile virus is endemic in multiple European countries and responsible for several epidemics throughout the European region. Its evolution into local or even widespread epidemics is driven by multiple factors from genetic diversification of the virus to environmental conditions. The year of 2018 was characterized by an extraordinary increase in human and animal cases in the Central-Eas...
Source: Viruses - Category: Virology Authors: Tags: Brief Report Source Type: research
Viruses, Vol. 12, Pages 104: An RNA Thermometer Activity of the West Nile Virus Genomic 3′-Terminal Stem-Loop Element Modulates Viral Replication Efficiency during Host Switching Viruses doi: 10.3390/v12010104 Authors: Alexandra Meyer Marie Freier Tobias Schmidt Katja Rostowski Juliane Zwoch Hauke Lilie Sven-Erik Behrens Susann Friedrich The 3′-terminal stem-loop (3′SL) of the RNA genome of the flavivirus West Nile (WNV) harbors, in its stem, one of the sequence elements that are required for genome cyclization. As cyclization is a prerequisite for the initiation of viral rep...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In this study, the in vitro antiviral activity of sofosbuvir against West Nile virus (WNV) was determined by plaque assay (PA) and Immunodetection Assay (IA) in human cell lines and by enzymatic RdRp assay. By PA, the sofosbuvir half-maximal inhibitory concentration (IC50) was 1.2 ± 0.3 μM in Huh-7, 5.3 ± 0.9 μM in U87, 7.8 ± 2.5 μM in LN-18 and 63.4 ± 14.1 μM in A549 cells. By IA, anti-WNV activity was confirmed in both hepatic (Huh-7, 1.7 ± 0.5 μM) and neuronal (U87, 7.3 ± 2.0 μM) cell types. Sofosbuvir was confirmed to inhi...
Source: Antiviral Therapy - Category: Virology Source Type: research
Authors: Camp JV, Nowotny N Abstract Introduction: West Nile virus (WNV) is a mosquito-borne human and animal pathogen with nearly world-wide distribution. In Europe, the virus is endemic with seasonal regional outbreaks that have increased in frequency over the last 10 years. A massive outbreak occurred across southern and central Europe in 2018 with the number of confirmed human cases increasing up to 7.2-fold from the previous year, and expanding to include previously virus-free regions.Areas covered: This review focuses on potential causes that may explain the 2018 European WNV outbreak. We discuss the role gen...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
In this study, the in vitro antiviral activity of sofosbuvir against West Nile virus (WNV) was determined by plaque assay (PA) and Immunodetection Assay (IA) in human cell lines and by enzymatic RdRp assay. By PA, the sofosbuvir half-maximal inhibitory concentration (IC50) was 1.2 ± 0.3 μM in Huh-7, 5.3 ± 0.9 μM in U87, 7.8 ± 2.5 μM in LN-18 and 63.4 ± 14.1 μM in A549 cells. By IA, anti-WNV activity was confirmed in both hepatic (Huh-7, 1.7 ± 0.5 μM) and neuronal (U87, 7.3 ± 2.0 μM) cell types. Sofosbuvir was confirmed to inhi...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
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