Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology.

We present the fabric of this process in (patho)physiology through the discussion of synthesis and metabolism of ATP and glutamate in astrocytes as well as by providing a general description of astroglial receptors for these molecules along with the downstream signaling pathways that may be activated. It is astroglial receptors for these dual-acting molecules that could hold a key for medical intervention in pathological conditions. We focus on two examples disclosing the role of activation of astroglial ATP and glutamate receptors in pathology of two kinds of brain tissue, gray matter and white matter, respectively. Interventions at the interface of metabolism and signaling show promise for translational medicine. PMID: 26915104 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26915104?dopt=Abstract

Source: Neurochemical Research - February 25, 2016 Category: Neuroscience Authors: Parpura V, Fisher ES, Lechleiter JD, Schousboe A, Waagepetersen HS, Brunet S, Baltan S, Verkhratsky A Tags: Neurochem Res Source Type: research