Lab-created sperm breeds healthy mice, raising hopes for end to male infertility

Scientists hail landmark achievement, but warn that artificial human sperm is a distant prospect fraught with concerns over safety, ethics and legalityA handful of healthy mice made from sperm cells created in the lab have been hailed as a milestone in research that could ultimately provide new treatments for male infertility.Scientists in China created the mice by fertilising normal mouse eggs with early-stage sperm cells that were manufactured from embryonic stem cells plucked from the animals. Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Stem cells Science Fertility problems Biology Reproduction Medical research Health Source Type: news

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Abstract Successful implantation and pregnancy is dependent on sufficient endometrial growth during each reproductive cycle. Here we report the therapeutic effect of either bone marrow-derived cells or the stem cell chemo-attractant CXCL12 on endometrial receptivity in a murine ethanol induced thin endometrium model. Endometrial epithelial area was significantly increased in mice treated with BMDCs, CXCL12 or by co-treatment with both compared with PBS treated controls. Ki-67 and CD31 immunoreactivity was significantly higher in mice treated with either BMDCs, CXCL12 or both. The mRNA expression levels of endometr...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
AbstractAsherman ’s Syndrome (AS) is an acquired condition defined by the presence of intrauterine adhesions (IUA) that cause symptoms such as menstrual abnormalities, pelvic pain, infertility, recurrent miscarriage, abnormal placentation and attendant psychological distress. Classically, AS is considered an iatro genic disease triggered by trauma to the pregnant uterus. Different factors can cause the destruction of the endometrium, thus affecting the endometrial stem cell niche and creating IUAs. Curettage of the pregnant uterus appears to be the most common source of this destruction. Nevertheless, some AS cases h...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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