Meta-analysis of the association between a serotonin transporter 5-HTTLPR polymorphism and smoking cessation

5-HTTLPR is one of the candidate genes influencing addiction. Recent studies have reported that the 5-HTTLPR genotype is associated with smoking behaviour, but its influence is still controversial. Thus, we reviewed the smoking-cessation outcomes among previously reported studies by comparing the 5-HTTLPR polymorphism. In total, eight studies including 3206 participants for the present meta-analysis were assessed and the S/S, S/L and L/L genotypes were compared with respect to smoking-cessation outcomes. The results of comparing 5-HTTLPR genotypes were as follows: odds ratio (OR)=1.044 and 95% confidence interval (CI)=0.751–1.078 for S/S versus S/L; OR=0.862 and 95% CI=0.690–1.077 for S/L versus L/L; and OR=0.924 and 95% CI=0.689–1.433 for S/S versus L/L. We found no significant association between 5-HTTLPR and smoking cessation, but 5-HTTLPR remains an important smoking-related candidate gene.
Source: Psychiatric Genetics - Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research