Pathophysiology of interstitial cystitis/bladder pain syndrome

Publication date: December 2015 Source:Tzu Chi Medical Journal, Volume 27, Issue 4 Author(s): Qian-Shen Ke, Hann-Chorng Kuo Interstitial cystitis (IC) is a heterogeneous syndrome characterized by bladder pain and is associated with frequency and nocturia. Research findings have proposed several pathophysiological mechanisms including epithelial dysfunction, activation of mast cells, neurogenic inflammation, autoimmunity, and occult infection. One of the most common findings in IC bladders is denudation or thinning of the bladder epithelium, suggesting an altered regulation of urothelial homeostasis. Different phenotypes of IC have been explored including Hunner and nonHunner type IC (ulcer and nonulcer type IC), hypersensitive bladder, and bladder pain with and without functional somatic syndrome. Different gene expressions have been found in different IC phenotypes. Augmented purinergic signaling in the bladder has been found in IC. Significant increases in antiproliferative factor, decreases in heparin-binding epidermal growth factor, and increased levels of epidermal growth factor have been discovered. Abnormal cytokine secretion in IC bladders has also been related to an increase in purinergic signaling, which mediates increased bladder sensation. Abnormal expression of uroplakins, chondroitin sulfate, junction protein E-cadherin, and tight junctional protein zonula occludens-1, strongly suggests abnormal epithelial differentiation in IC bladders. The increased apopto...
Source: Tzu Chi Medical Journal - Category: Universities & Medical Training Source Type: research

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Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
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Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
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Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
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