Tryptophan Catabolites and Their Impact on Multiple Sclerosis Progression.
Tryptophan Catabolites and Their Impact on Multiple Sclerosis Progression. Curr Pharm Des. 2016;22(8):1049-59 Authors: Watzlawik JO, Wootla B, Rodriguez M Abstract Accumulating evidence demonstrates involvement of tryptophan metabolites and in particular activation of the kynurenine pathway (KP) in neurocognitive disorders under CNS inflammatory conditions. The KP is involved in several brain-associated disorders including Parkinson's disease, AIDS dementia, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, schizophrenia, and brain tumors. Our review is an attempt to address any relevant association between dysregulation of KP and multiple sclerosis (MS), an inflammatory CNS disorder that ultimately leads to demyelinated brain areas and severe neurological deficits. Modulation of KP is a new topic for the field of MS and warrants further research. The availability of potential KP modulators approved for MS may shed some light into the therapeutic potential of KP antagonists for the treatment of MS patients. PMID: 26899126 [PubMed - in process]
Conclusions: Singing and music can be powerful and useful tools in the care of and in communication with persons with dementia. Regardless of whether singing or music is used, the most important factor is that a person-centred approach is adopted so as to make the music a facilitative tool. Caregiver singing and music are ways to connect with the person with dementia and an understanding of their use can contribute to dementia research. This in turn can increase awareness of the possible ways to strengthen the partnership between caregivers and persons with dementia. PMID: 32212959 [PubMed - in process]
Conclusions: In the present situation delusional ideas are no longer mentioned, but a cognitive deduction is found. Aripiprazole can be an effective pharmacological solution for the psychotic symptoms in patients suffering from 22q11DS. PMID: 32214520 [PubMed - in process]
Publication date: 28 March 2020Source: New Scientist, Volume 245, Issue 3275Author(s): Clare Wilson
In the face of COVID-19, neurologists working in stroke, epilepsy, dementia, and other subspecialties are tasked with a quick pivot from in-office patient visits to a new era of online consultations.Medscape Medical News
CONCLUSION: Physicians play an important role with respect to the persistence of the dementia patients they treat. Further studies are needed to better understand the role of physicians of other specialties in patients' adherence. . PMID: 32213286 [PubMed - as supplied by publisher]
Publication date: Available online 27 March 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Gavin Giovannoni, Chris Hawkes, Jeannette Lechner-Scott, Michael Levy, Emmanuelle Waubant, Julian Gold
Publication date: Available online 27 March 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Christopher H. Hawkes, Gavin Giovannoni, Michael Levy, Jeanette Lechner-Scott, Emmanuelle Waubant
Publication date: Available online 28 March 2020Source: Journal of Clinical NeuroscienceAuthor(s): Wen Wang, Junsheng Li, Fa Lin, Jia Guo, Jizong Zhao
Abstract Mutations in isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase promoter (TERTp) exert a far-reaching influence on clinicopathologic diagnosis and prognosis of glioma. Traditional approaches, such as Sanger sequencing and ARMS, lack sensitivity due to tumor heterogeneity and low tumor purity of glioma samples. Therefore, we propose a highly sensitive detection method for IDH1 and TERTp mutations based on ddPCR technology, named IDH1-TERT-mutation ddPCR (IT-ddPCR). We determined the IDH1 and TERTp mutations of 80 patients by Sanger sequencing, ARMS, and IT-ddPCR in parallel. We detected th...
CONCLUSIONS DEGs, including SORT1, CRYAB, PSMA1, and SDHA may have roles in the pathogenesis of PD through the MAPK, Wnt, and Notch signaling pathways. PMID: 32210219 [PubMed - in process]