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Male Childhood Cancer Survivors Less Likely to Have Kids, Study Finds

But Norwegian researchers also found no increased risk of birth defects or delivery complications Source: HealthDay Related MedlinePlus Pages: Cancer in Children, Male Infertility
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news

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Cancer, EarlyView.
Source: Cancer - Category: Cancer & Oncology Authors: Source Type: research
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Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Short Report Source Type: research
AbstractAdult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically. By contrast, radiation is detrimental to both the ovaries and the uterus, thereby causing a gr...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Review, Gynecologic Oncology Source Type: research
Authors: Gravholt CH, Chang S, Wallentin M, Fedder J, Moore P, Skakkebæk A Abstract Although first identified over 70 years ago, Klinefelter syndrome (KS) continue to pose significant diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed. In fact, as few as 25% of KS patients are accurately diagnosed, and most of these diagnoses are not made until adulthood. Classic characteristics of KS include small testes, infertility, hypergonadothropic hypogonadism, and cognitive impairment. However, the pathophysiology behind KS is not well understood, although genetic effects are also th...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
UCLA researchers have made new inroads into understanding germ cell tumors, a diverse and rare group of cancers that begin in germ cells — the cells that develop into sperm and eggs. The researchers developed a protocol to recreate germ cell tumor cells from stem cells and used the new model to study the genetics of the cancer.Their findings could point the way toward new drugs to treat germ cell tumors, which account for around 3 percent of all cases of childhood and adolescent cancer.The study, published in Stem Cell Research, was led by Amander Clark, a UCLA professor of molecular cell and developmental biology an...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Abstract Adult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically. By contrast, radiation is detrimental to both the ovaries and the uterus, thereby ca...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
As The Author of Minding Our Elders: Caregivers Share Their Personal Stories, I'm honored to be chosen to be part AlzAuthors. This post is courtesy of AlzAuthors. Read through for some incredible deals on ebooks written by authors who've been where you are. MOE is among the books on sale. All are $2.99 or less. November is National Caregiver Appreciation Month, a time to recognize the long hours, sacrifice, and love all caregivers bring to the task of caring for a loved one with dementia or any long-term illness. In honor of their efforts, AlzAuthors is hosting an eBook sale and giveaway! This is a terrific way f...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Publication date: Available online 26 October 2017 Source:Best Practice & Research Clinical Obstetrics & Gynaecology Author(s): Gabriela N. Algarroba, Joseph S. Sanfilippo, Hanna Valli-Pulaski The 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future due to the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all p...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
AbstractThere is substantial evidence that paternal obesity is associated not only with an increased incidence of infertility, but also with an increased risk of metabolic disturbance in adult offspring. Apparently, several mechanisms may contribute to the sperm quality alterations associated with paternal obesity, such as physiological/hormonal alterations, oxidative stress, and epigenetic alterations. Along these lines, modifications of hormonal profiles namely reduced androgen levels and elevated estrogen levels, were found associated with lower sperm concentration and seminal volume. Additionally, oxidative stress in t...
Source: Basic and Clinical Andrology - Category: Urology & Nephrology Source Type: research
One of the most important things my mother taught me was to choose my friends intelligently. From a very young age, I remember my mother quoting Proverbs to me and telling me this, “Choose your counsel wisely.” The older I get, the more I believe who I allow to influence me plays an enormous part in the place I find myself in today. Research has shown you become like the five people you spend the most time with. I would argue that you also see the world through the eyes of those who you listen to the most. This is why I choose very carefully who I allow into my daily life, and why I find myself every few months...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Practice Management Primary Care Source Type: blogs
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