What's in the Literature?

Abstract: In this issue, we review clinical features associated with an elevated serum creatine kinase level found in a percentage of patients with amyotrophic lateral sclerosis (ALS). The treatment of ALS remains problematic, and issues with offerings on the internet for unregulated stem cell treatment and the movement for right-to-try experimental drugs are discussed. The last What's in the Literature? discussed information about recording from stimulating electrodes implanted in the diaphragm of ALS patients, and this issue discusses the results of a randomized trial using diaphragm pacing. Chronic inflammatory demyelinating polyradiculoneuropathy is important to diagnose, as it is one of the few treatable chronic neuropathies. However, the diagnosis can be challenging to make, and a review of diagnostic errors is discussed. Once diagnosed, treatment management can be difficult, and endpoint measures are discussed. Updates on the use of mycophenolate mofetil and cyclophosphamide in the treatment of myasthenia gravis are reviewed, as they are the use of cell-based assays for detecting antibodies to clustered acetylcholine receptors. Factors associated with life-threatening events in myasthenia, ethnic differences in the course of the disease, and treatment in very elderly patients are also discussed. Hematopoietic stem cell transplantation as a treatment of mitochondrial neurogastrointestinal encephalomyopathy is reviewed. A natural history study in boys with Duchenne muscu...
Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Literature Review Source Type: research

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Authors: Kerekes K, Bányai L, Trexler M, Patthy L Abstract Wnts and Hedgehogs (Hh) are large, lipid-modified extracellular morphogens that play key roles in embryonic development and stem cell proliferation of Metazoa. Both morphogens signal through heptahelical Frizzled-type receptors of the G-Protein Coupled Receptor family and there are several other similarities that suggest a common evolutionary origin of the Hh and Wnt pathways. There is evidence that the secreted protein, Wnt inhibitory factor 1 (WIF1) modulates the activity of both Wnts and Hhs and may thus contribute to the intertwining of these pat...
Source: Growth Factors - Category: Research Tags: Growth Factors Source Type: research
Authors: Lee S, Lee H, Eun LY, Gang SW Abstract PMID: 31208158 [PubMed - in process]
Source: Korean Journal of Pediatrics - Category: Pediatrics Tags: Korean J Pediatr Source Type: research
Publication date: 1 September 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 181Author(s): Marie Dubus, Hassan Rammal, Halima Alem, Nicolae B. Bercu, Isabelle Royaud, Fabienne Quilès, Fouzia Boulmedais, Sophie C. Gangloff, Cedric Mauprivez, Halima KerdjoudjAbstractThe regeneration of bone-soft tissue interface, using functional membranes, remains challenging and can be promoted by improving mesenchymal stem cells (MSCs) paracrine function. Herein, a collagen membrane, used as guided bone regeneration membrane, was functionalized by calcium phosphate, chitosan and hyaluronic acid hybrid coating by simulta...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 19 June 2019Source: Chemico-Biological InteractionsAuthor(s): Yeonhwa Song, I-Seul Park, Jiho Kim, Inhee Choi, Haeng Ran SeoAbstractLiver cancer is one of the most frequently occurring types of cancer with high mortality rate. Hepatocellular carcinoma (HCC) frequently metastasizes to lung, portal vein, and portal lymph nodes and most HCCs show strong resistance to conventional anticancer drugs. Cancer stem cells (CSCs) are considered to be responsible for resistance to therapies. Hence, recent advancements in the use of liver cancer stem cells (LCSCs) are rapidly gaining recognition as an...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
This study reports characterization of the first breast cancer bone growth model in huNOG mice. BT-474 tumors represent a "cold" tumor with a low number of TILs. This model can be used for evaluating the efficacy of combination treatments of IO therapies with immune-stimulatory compounds or therapeutic approaches on bone metastatic breast cancer. PMID: 31211147 [PubMed - in process]
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Authors: Oba R, Isomura M, Igarashi A, Nagata K Abstract Extracellular vesicles (EVs) are known to contain unique proteins that reflect the cells of origins. Activated T cells are reported to secrete various EVs. To establish T cell subset-specific biomarkers, we performed proteomic analysis with Th1- and Th2-derived EVs and identified HLA-DR as a Th1-dominated EV membrane protein. We designed a measurement system for CD3+CD4+, CD3+CD8+, and CD3+HLA-DR+ EVs to specifically determine EV subpopulations derived from CD4+, CD8+, and Th1-type T cells, respectively. In vitro analysis showed that CD3+CD4+ EVs and CD3+CD8+...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Authors: Costanza M Abstract Type 2 immunity has long been confined to a restricted spectrum of responses, mostly including allergic reactions to innocuous environmental triggers. However, growing evidence suggests that cells and mediators typically associated with type 2 inflammation are involved in several physiopathological conditions, such as defense against toxic substances, anticancer immunity, and autoimmune diseases. In neuromyelitis optica, an autoimmune demyelinating disorder of the spinal cord and optic nerve, eosinophils extensively infiltrate lesions in the central nervous system (CNS) and promote tiss...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
In conclusion, TSAs improve diagnosis of pSS in the early stage, especially in anti-SSA-negative patients, and their tissue-specific nature indicates localized salivary injury, which deserves further studies to clarify the mechanism. PMID: 31205955 [PubMed - in process]
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Publication date: Available online 18 June 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Dan Hu, WeiBing Si, XuePing Gu, Wei Qin, Jian Jiao, YueFeng HaoAbstractThe latent utilization of biomaterials that are osteo-conducive in the advancement of healing bone fracture has fascinated extensive consideration. This work includes the synthesis of silver nanoparticles (AgNPs) with the help of a Bauhinia acuminate plant flower extract through an ecofriendly synthetic process without any use of harmful reductants. In the fabrication of AgNPs, Bauhinia acuminate plant flower extract bio constituents ac...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
We examined the efficacy of 2 supplementary KT education approaches delivered directly to patients.Study DesignProspective, 3-arm parallel-group, randomized, controlled trial.Settings &ParticipantsAdult, black, and white low-income patients receiving dialysis in Missouri.InterventionPatients were randomly assigned to 1 of 3 educational conditions: (1) standard of care, usual KT education provided in dialysis centers (control); (2) Explore Transplant @ Home patient-guided, 4 modules of KT education sent directly to patients using print, video, and text messages; and (3) Explore Transplant @ Home educator-guided, the pat...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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