Why walking by a main road is as bad for you as smoking

William Phin, six, from Whitley Bay, north of Newcastle, has obliterative bronchiolitis - which may be triggered by pollution. A lung transplant is the only cure.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Pulmonary compromise has been shown to significantly contribute to non-relapse mortality after hematopoietic stem cell transplantation (or HSCT).1-4 The etiology of these pulmonary complications includes intrapulmonary causes of fibrosis and toxicities from treatment regimens or infections (restrictive lung disease), graft-versus-host disease or bronchiolitis obliterans syndrome (obstructive lung disease), and vascular abnormalities (e.g. pulmonary hypertension), as well as extrapulmonary causes such as weakness or sclerodermatous GVHD.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
There is a need for non-invasive parameters that are sensitive to the development of the bronchiolitis obliterans syndrome (BOS) in lung transplantation (LTx) patients. We studied whether the pulmonary diffusi...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
The 21st Transplant Registry Report summarizes data from pediatric lung and heart/lung transplant recipients and their donors for transplants that occurred through June 30, 2017. This year's report focuses on an overall theme of multiorgan transplantation. In addition to reporting key data for all adult lung and heart-lung transplant recipients, we report transplant types, historical trends, geographical associations, indications, donor and recipient characteristics and transplant outcomes including rejection burden, bronchiolitis obliterans syndrome (BOS), and survival for multiorgan transplant recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
CONCLUSIONS In selected lung transplant recipients, early sirolimus-based immunosuppression is safe and associated with beneficial short-term and long-term outcomes. PMID: 30135417 [PubMed - in process]
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
Chronic rejection is the Achilles heel of modern lung transplantation, characterized by a slow, progressive decline in allograft function. Clinically, this manifests as obstructive disease, restrictive disease, or a mixture of the 2 depending on the underlying pathology. The 2 major phenotypes of chronic rejection include bronchiolitis obliterans syndrome and restrictive allograft syndrome. The last decade of research has revealed that each of these phenotypes has a unique underlying pathophysiology which may require a distinct treatment regimen for optimal control. Insights into the intricate alloimmune pathways contribut...
Source: Transplantation - Category: Transplant Surgery Tags: Reviews Source Type: research
CONCLUSION: LR is a therapeutic option in selected patients with CLAD, with acceptable survival. Indication for LR early after LT shows poor outcomes. PMID: 30131203 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - Category: Respiratory Medicine Authors: Tags: Arch Bronconeumol Source Type: research
The diagnostic criteria for antibody-mediated rejection (AMR) after lung transplantation (LTx) includes immunohistochemistry (IHC) staining patterns for C4d but not C3d.1 Historically, C3d deposition is a recognized complication after LTx associated with primary graft dysfunction and early bronchiolitis obliterans syndrome (BOS)2,3 but is not widely used in LTx even though it's a result of complement deposition via the classical pathway.4 The International Society for Heart and Lung Transplantation Pathology Council established a threshold of>50% deposition of C4d in interstitial capillaries as diagnostic but emphasized...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research
AbstractComplications following lung transplantation may impede allograft function and threaten patient survival. The five main complications after lung transplantation are primary graft dysfunction, post-surgical complications, alloimmune responses, infections, and malignancy.Primary graft dysfunction, a transient ischemic/reperfusion injury, appears as a pulmonary edema in almost every patient during the first three days post-surgery.Post-surgical dysfunction could be depicted on computed tomography (CT), such as bronchial anastomosis dehiscence, bronchial stenosis and bronchomalacia, pulmonary artery stenosis, and size ...
Source: Insights into Imaging - Category: Radiology Source Type: research
Publication date: September 2018Source: Academic Radiology, Volume 25, Issue 9Author(s): Eduardo J. Mortani Barbosa, Maarten Lanclus, Wim Vos, Cedric Van Holsbeke, William De Backer, Jan De Backer, James LeeRationale and ObjectivesLong-term survival after lung transplantation (LTx) is limited by bronchiolitis obliterans syndrome (BOS), defined as a sustained decline in forced expiratory volume in the first second (FEV1) not explained by other causes. We assessed whether machine learning (ML) utilizing quantitative computed tomography (qCT) metrics can predict eventual development of BOS.Materials and MethodsPaired inspirat...
Source: Academic Radiology - Category: Radiology Source Type: research
The FDA warns of an increased risk for relapse of hematologic malignancy and for death when azithromycin is used to prevent bronchiolitis obliterans syndrome in hematopoietic stem cell transplant patients.News Alerts
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news
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