Steroid May Be Safe, Effective Gout Treatment, Study Finds

MONDAY, Feb. 22, 2016 -- A steroid pill may be as good as a nonsteroidal anti-inflammatory drug (NSAID) for treating painful gout, new research suggests. Researchers who compared the steroid prednisolone with the arthritis medication indomethacin...
Source: Drugs.com - Daily MedNews - Category: Journals (General) Source Type: news

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Conclusions: This study demonstrated for the first time that BHA exhibits anti-inflammatory, antioxidative and antihyperuricemic effects in vivo, suggesting a potential therapeutic application of BHA in gouty arthritis and hyperuricemia. PMID: 31622116 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
by Xue Li, Xiangrui Meng, Yazhou He, Athina Spiliopoulou, Maria Timofeeva, Wei-Qi Wei, Aliya Gifford, Tian Yang, Tim Varley, Ioanna Tzoulaki, Peter Joshi, Joshua C. Denny, Paul Mckeigue, Harry Campbell, Evropi Theodoratou BackgroundThe role of urate in cardiovascular diseases (CVDs) has been extensively investigated in observational studies; however, the extent of any causal effect remains unclear, making it difficult to evaluate its clinical relevance. Methods and findingsA phenome-wide association study (PheWAS) together with a Bayesian analysis of tree-structured phenotypic model (TreeWAS) was performed to examine disea...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Three clinical experts on gout offer their insights into common management errors, clinical pearls, new safety data from the FDA and the role of biologic therapies in the management of gout.
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Biologics & Biosimilars Conditions Crystal Arthritis DMARDs & Immunosuppressives Drug Updates Gout Source Type: research
In 1975, researchers from Yale investigated an epidemic of 51 patients with arthritis who lived near the woodsy town of Lyme, Connecticut. The most common symptom was recurrent attacks of knee swelling. A few had pain in other joints, such as the wrist or ankle. Many had fever, fatigue, and headache. Some remembered a round skin rash before the onset of knee swelling. We now know that Lyme disease is an infection acquired from tick bites, caused by a spiral bacterium named Borrelia burgdorferi. After a tick bite, Borrelia bacteria wriggle through the skin away from the bite site. This leads to a circular red rash, known as...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Arthritis Bones and joints Infectious diseases Source Type: blogs
Title: Some May Be Vulnerable to Severe Skin Reaction While Using Gout DrugCategory: Health NewsCreated: 10/1/2019 12:00:00 AMLast Editorial Review: 10/2/2019 12:00:00 AM
Source: MedicineNet Arthritis General - Category: Rheumatology Source Type: news
Rationale: The pathology of gouty arthritis and reactive arthritis (ReA) partially overlaps, and both diseases are characterized by the production of inflammatory cytokines associated with the activation of monocytes and macrophages. However, the precise cytokine profile of cases with a coexistence of both diseases is unknown, and there are few reports on the course of treatment in patients with both gouty arthritis and ReA. Patient concerns: A 39-year-old man with a recurrent episode of gouty arthritis presented prednisolone-resistant polyarthritis with high level of C-reactive protein (CRP). He had the features of g...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
NEW YORK (Reuters Health)—Dual energy computed tomography (DECT) can differentiate cardiovascular monosodium urate (MSU) deposits from calcium deposits in patients with gout, potentially identifying those at risk of heart disease, researchers say. Sylvia Strobl, MD, of Medical University Innsbruck and colleagues analyzed calcium scores and MSU deposits in 59 patients with gout (mean age: 59;... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Crystal Arthritis cardiovascular dual energy computed tomography Gout Heart Disease imaging Source Type: research
(Reuters Health)—Behavior changes could potentially reduce a large part of the risk for developing gout, a U.S. study suggests. Based on data from more than 14,000 people, researchers calculated how much factors like being overweight, following a diet that isn’t heart healthy, drinking alcohol or taking diuretics contribute to high levels of uric acid—a precursor... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Crystal Arthritis Alcohol Arthritis & Rheumatology Gout lifestyle Obesity Risk Factors Source Type: research
ConclusionSeveral non ‐CV causes of mortality are increased in persons with gout, emphasizing the need for improved management of comorbidities.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
This study investigates the association between exposure to urate-lowering drugs (ULDs) and progression and recovery from chronic kidney disease (CKD).
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
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